Detailed information of TA system TA168848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 13358..14246
• Replicon: plasmid pCFV_08A1102_P1
• Accession: NZ_CP059440
• Organism: Campylobacter fetus strain CFV08A1102-42A

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: GZ987_RS10230
• Protein ID: WP_181912978.1
• Coordinates: 13358..14014 (-)
• Length: 219 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: -
• Locus tag: GZ987_RS10235
• Protein ID: WP_181912979.1
• Coordinates: 13998..14246 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZ987_RS10185	8431..8781	-	351	WP_002851003.1	hypothetical protein	-
GZ987_RS10190	8778..9053	-	276	WP_035148435.1	type II toxin-antitoxin system YafQ family toxin	-
GZ987_RS10195	9046..9261	-	216	WP_035148437.1	hypothetical protein	-
GZ987_RS10200	9476..9844	+	369	WP_065842670.1	DNA transfer protein	-
GZ987_RS10205	9819..11381	+	1563	WP_181912977.1	relaxase/mobilization nuclease domain-containing protein	-
GZ987_RS10210	11461..11670	-	210	WP_002850993.1	hypothetical protein	-
GZ987_RS10215	11674..12360	-	687	WP_002850991.1	AAA family ATPase	-
GZ987_RS10220	12471..12842	-	372	WP_002850989.1	hypothetical protein	-
GZ987_RS10225	12839..13297	-	459	WP_059435589.1	S26 family signal peptidase	-
GZ987_RS10230	13358..14014	-	657	WP_181912978.1	Fic family protein	Toxin
GZ987_RS10235	13998..14246	-	249	WP_181912979.1	hypothetical protein	Antitoxin
GZ987_RS10240	14363..15070	-	708	WP_181912980.1	conjugal transfer protein TraL	-
GZ987_RS10245	15082..16908	-	1827	WP_065839001.1	type IV secretory system conjugative DNA transfer family protein	-
GZ987_RS10250	16918..19107	-	2190	WP_181912981.1	DUF1738 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..37205	37205

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (50-158)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 219 a.a.
• Molecular weight: 25151.06 Da
• Isoelectric Point: 10.1737

>T168848 WP_181912978.1 NZ_CP059440:c14014-13358 [Campylobacter fetus]
MKESNEELFKKLIADNKLGIKDEKLFDKESRKYTLVRTKEIIKTPIKGNFDYQHLKNIHKYIFQDVFHWAGKDRMEVGLH
GNFGKYAPNGTITNFVPGKDLNATAQQIFTWLKEDNYLKNSKDLNDFAKNLAEFARNLNALHPFREGNGRTQRIFLNELT
KNVGYKLDLNLIPKNKMIMASVEASQLKLGKLEALIKTNLKSFKQNLEKENALGLSLC

Nucleotide

• Length: 657 bp

>T168848 NZ_CP076245:3657503-3657889 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9614.88 Da
• Isoelectric Point: 4.3896

>AT168848 WP_181912979.1 NZ_CP059440:c14246-13998 [Campylobacter fetus]
MTYPEVHSLEESLAILKKYKDDVSKKDYEEIKSTICGHAIEDIFANEEDIIMLVKMSTYNLSSDEILAEYKEKGFVEYER
KQ

Nucleotide

• Length: 249 bp

>AT168848 NZ_CP076245:3657879-3658208 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTATCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA