168847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) fic-relB/Fic-Fic
Location 567..2323 Replicon plasmid pCFV_08A1102_P1
Accession NZ_CP059440
Organism Campylobacter fetus strain CFV08A1102-42A

Toxin (Protein)


Gene name Fic Uniprot ID C5H2Y4
Locus tag GZ987_RS10135 Protein ID WP_002850956.1
Coordinates 567..1487 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name Fic Uniprot ID B2CG46
Locus tag GZ987_RS10140 Protein ID WP_002850958.1
Coordinates 1487..2323 (-) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ987_RS10130 298..567 - 270 WP_035148454.1 hypothetical protein -
GZ987_RS10135 567..1487 - 921 WP_002850956.1 Fic family protein Toxin
GZ987_RS10140 1487..2323 - 837 WP_002850958.1 Fic family protein Antitoxin
GZ987_RS10145 2327..2629 - 303 WP_080582791.1 DUF86 domain-containing protein -
GZ987_RS10150 2751..3062 - 312 WP_002850963.1 nucleotidyltransferase domain-containing protein -
GZ987_RS10155 3130..3792 - 663 WP_002850964.1 AAA family ATPase -
GZ987_RS10160 3927..5027 - 1101 WP_166428600.1 transposase -
GZ987_RS10165 5005..5460 - 456 WP_010404250.1 IS200/IS605 family transposase -
GZ987_RS10170 5826..6239 - 414 WP_046037538.1 type II toxin-antitoxin system VapC family toxin -
GZ987_RS10175 6236..7066 - 831 WP_081303298.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37205 37205
- flank IS/Tn - - 5005..5460 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(91-202)

Antitoxin

Fido domain

(85-182)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 35445.26 Da        Isoelectric Point: 9.2339

>T168847 WP_002850956.1 NZ_CP059440:c1487-567 [Campylobacter fetus]
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKGHKSEKSVLSRLGAAYDKKVQSGAIKQPQISKKSKEKER

Download         Length: 921 bp

>T168847 NZ_CP076245:3482011-3482298 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 31851.33 Da        Isoelectric Point: 8.5962

>AT168847 WP_002850958.1 NZ_CP059440:c2323-1487 [Campylobacter fetus]
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER

Download         Length: 837 bp

>AT168847 NZ_CP076245:3481820-3482011 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D7L3Y5

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7Q668

References