168846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) fic-relB/Fic-Fic
Location 21643..23399 Replicon plasmid pCFVi_ADRI545_P1
Accession NZ_CP059438
Organism Campylobacter fetus strain CFViADRI545

Toxin (Protein)


Gene name Fic Uniprot ID C5H2Y4
Locus tag GZ988_RS10780 Protein ID WP_002850956.1
Coordinates 22479..23399 (+) Length 307 a.a.

Antitoxin (Protein)


Gene name Fic Uniprot ID B2CG46
Locus tag GZ988_RS10775 Protein ID WP_002850958.1
Coordinates 21643..22479 (+) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ988_RS10735 17168..18388 + 1221 WP_065842451.1 hypothetical protein -
GZ988_RS10740 18385..18639 + 255 WP_010400630.1 hypothetical protein -
GZ988_RS10745 18636..18851 + 216 WP_002850970.1 hypothetical protein -
GZ988_RS10750 19054..19764 + 711 WP_002850968.1 hypothetical protein -
GZ988_RS10755 19832..20149 + 318 WP_010400644.1 hypothetical protein -
GZ988_RS10760 20174..20836 + 663 WP_002850964.1 AAA family ATPase -
GZ988_RS10765 20904..21215 + 312 WP_002850963.1 nucleotidyltransferase domain-containing protein -
GZ988_RS10770 21337..21639 + 303 WP_080582791.1 DUF86 domain-containing protein -
GZ988_RS10775 21643..22479 + 837 WP_002850958.1 Fic family protein Antitoxin
GZ988_RS10780 22479..23399 + 921 WP_002850956.1 Fic family protein Toxin
GZ988_RS10785 23399..23668 + 270 WP_035148454.1 hypothetical protein -
GZ988_RS10790 23677..25014 - 1338 WP_035148452.1 hypothetical protein -
GZ988_RS10795 25011..25574 - 564 WP_035148446.1 hypothetical protein -
GZ988_RS10800 26255..26410 + 156 WP_158004718.1 hypothetical protein -
GZ988_RS10805 26530..27354 + 825 WP_181913650.1 hypothetical protein -
GZ988_RS10810 27351..27764 + 414 WP_046037538.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48693 48693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(91-202)

Antitoxin

Fido domain

(85-182)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 35445.26 Da        Isoelectric Point: 9.2339

>T168846 WP_002850956.1 NZ_CP059438:22479-23399 [Campylobacter fetus]
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKGHKSEKSVLSRLGAAYDKKVQSGAIKQPQISKKSKEKER

Download         Length: 921 bp

>T168846 NZ_CP076245:c3267664-3267290 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 31851.33 Da        Isoelectric Point: 8.5962

>AT168846 WP_002850958.1 NZ_CP059438:21643-22479 [Campylobacter fetus]
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER

Download         Length: 837 bp

>AT168846 NZ_CP076245:c3268085-3267711 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D7L3Y5

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7Q668

References