Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 11902..12775 Replicon plasmid pCFVi_ADRI545_P1
Accession NZ_CP059438
Organism Campylobacter fetus strain CFViADRI545

Toxin (Protein)


Gene name Fic Uniprot ID A0A7D7Q4V2
Locus tag GZ988_RS10695 Protein ID WP_035171229.1
Coordinates 12134..12775 (+) Length 214 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A7D7Q4R1
Locus tag GZ988_RS10690 Protein ID WP_035171227.1
Coordinates 11902..12150 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ988_RS10670 6917..7069 + 153 WP_162832119.1 hypothetical protein -
GZ988_RS10675 7059..9230 + 2172 WP_035171221.1 DUF1738 domain-containing protein -
GZ988_RS10680 9243..11078 + 1836 WP_035171223.1 type IV secretory system conjugative DNA transfer family protein -
GZ988_RS10685 11075..11782 + 708 WP_035171225.1 conjugal transfer protein TraL -
GZ988_RS10690 11902..12150 + 249 WP_035171227.1 hypothetical protein Antitoxin
GZ988_RS10695 12134..12775 + 642 WP_035171229.1 Fic family protein Toxin
GZ988_RS10700 12837..13304 + 468 WP_065845967.1 signal peptidase I -
GZ988_RS10705 13291..13662 + 372 WP_035171233.1 conjugal transfer protein TraM -
GZ988_RS10710 13763..14449 + 687 WP_035171236.1 AAA family ATPase -
GZ988_RS10715 14452..14667 + 216 WP_035171239.1 hypothetical protein -
GZ988_RS10720 14740..15009 - 270 WP_161782547.1 hypothetical protein -
GZ988_RS10725 15087..16379 - 1293 WP_181913635.1 transposase -
GZ988_RS10730 16366..17004 - 639 WP_040126349.1 IS607 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48693 48693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(50-154)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 214 a.a.        Molecular weight: 24895.65 Da        Isoelectric Point: 9.5773

>T168845 WP_035171229.1 NZ_CP059438:12134-12775 [Campylobacter fetus]
MKESNEELFKKLIADNKLGIKDEKLFDKESRKYTLVRTKEIIKTPIKGNFDYQHLKNIHKYIFQDVFRWAGKDRNDMKIY
GFMSKENSVFCAGEYIPKEAEKIFTNLENQNYFKDCKDLNHFAKNISNFMSDLNALHPFREGNGRTQRIFINQLAKNAGY
KLDLNLIPKEKMTTASIEAMECKNNKLEALIKTNLKSFKQNLDRDCGVGLSLD

Download         Length: 642 bp

>T168845 NZ_CP076245:2951311-2951418 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9640.92 Da        Isoelectric Point: 4.2900

>AT168845 WP_035171227.1 NZ_CP059438:11902-12150 [Campylobacter fetus]
MTYPEVYSLEESLAILKKYKDDVSKKDYEEIKSTICGHAIEDIFANEEDIIMLVKMSTYNLSSDEILAEYKEKGFVEYER
KQ

Download         Length: 249 bp

>AT168845 NZ_CP076245:c2951258-2951197 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D7Q4V2

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7Q4R1

References