Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 9589..10504 Replicon plasmid pCFViADRI1362_P1
Accession NZ_CP059433
Organism Campylobacter fetus strain CFViADRI1362

Toxin (Protein)


Gene name Fic Uniprot ID A0A974RKV0
Locus tag GZ989_RS11065 Protein ID WP_024305403.1
Coordinates 9818..10504 (+) Length 229 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A974MUU2
Locus tag GZ989_RS11060 Protein ID WP_002850985.1
Coordinates 9589..9825 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ989_RS11045 4728..6917 + 2190 WP_024305405.1 DUF1738 domain-containing protein -
GZ989_RS11050 6927..8753 + 1827 WP_024305404.1 type IV secretory system conjugative DNA transfer family protein -
GZ989_RS11055 8765..9472 + 708 WP_002850984.1 conjugal transfer protein TraL -
GZ989_RS11060 9589..9825 + 237 WP_002850985.1 hypothetical protein Antitoxin
GZ989_RS11065 9818..10504 + 687 WP_024305403.1 Fic family protein Toxin
GZ989_RS11070 10715..11023 + 309 WP_051119553.1 S26 family signal peptidase -
GZ989_RS11075 11020..11391 + 372 WP_024305401.1 conjugal transfer protein TraM -
GZ989_RS11080 11502..12188 + 687 WP_024305400.1 AAA family ATPase -
GZ989_RS11085 12192..12407 + 216 WP_024305399.1 hypothetical protein -
GZ989_RS11090 12639..13094 + 456 WP_010404250.1 IS200/IS605 family transposase -
GZ989_RS11095 13072..14172 + 1101 WP_010404252.1 transposase -
GZ989_RS11100 14156..14779 - 624 WP_191002479.1 zeta toxin family protein -
GZ989_RS11105 14789..15022 - 234 WP_024305484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..40588 40588
- flank IS/Tn - - 12639..13094 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(60-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 229 a.a.        Molecular weight: 25978.99 Da        Isoelectric Point: 10.0098

>T168843 WP_024305403.1 NZ_CP059433:9818-10504 [Campylobacter fetus]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFKDVYTWA
GKDRMEVGLHGNFGKYAPNGTITNFVPGKDLNATAQQIFTWLKEDNYLTNSKDLNDFAKNLAEFARNLNALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLIPKDKMIMASVEASQLKLGKLEAIIKTNLKSFKQNLEKENTLGLSLC

Download         Length: 687 bp

>T168843 NZ_CP076245:c2703123-2702947 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9006.20 Da        Isoelectric Point: 4.3316

>AT168843 WP_002850985.1 NZ_CP059433:9589-9825 [Campylobacter fetus]
MTYPEVHSLEESLAILKKYKDDLTKEQYDGIKSIICGHAIEDMFANERDIIDMIKIAKNEANADEIIAEYKKEWGVND

Download         Length: 237 bp

>AT168843 NZ_CP076245:c2702901-2702485 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References