Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2380784..2381523 Replicon chromosome
Accession NZ_CP059422
Organism Enterobacter hormaechei strain ENCL49790

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag H1Z82_RS11405 Protein ID WP_003857133.1
Coordinates 2381038..2381523 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag H1Z82_RS11400 Protein ID WP_003857131.1
Coordinates 2380784..2381050 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1Z82_RS11380 2376260..2377246 + 987 WP_017382341.1 DUF979 domain-containing protein -
H1Z82_RS11385 2377256..2378251 + 996 WP_181494113.1 DUF2891 domain-containing protein -
H1Z82_RS11390 2378273..2379661 - 1389 WP_045142139.1 MFS transporter -
H1Z82_RS11395 2379791..2380720 + 930 WP_045142163.1 LysR family transcriptional regulator -
H1Z82_RS11400 2380784..2381050 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
H1Z82_RS11405 2381038..2381523 + 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
H1Z82_RS11410 2381574..2382143 - 570 WP_032648331.1 hypothetical protein -
H1Z82_RS11415 2382159..2383124 - 966 WP_032648329.1 hypothetical protein -
H1Z82_RS11420 2383403..2384805 + 1403 Protein_2228 ISNCY-like element ISKpn21 family transposase -
H1Z82_RS11425 2384834..2385466 - 633 WP_001567369.1 hypothetical protein -
H1Z82_RS11430 2385541..2386509 + 969 WP_022652343.1 IS5-like element IS903B family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T168835 WP_003857133.1 NZ_CP059422:2381038-2381523 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T168835 NZ_CP076245:408272-408799 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT168835 WP_003857131.1 NZ_CP059422:2380784-2381050 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT168835 NZ_CP076245:407999-408265 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References