Detailed information of TA system TA168828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1924432..1925043
• Replicon: chromosome
• Accession: NZ_CP059422
• Organism: Enterobacter hormaechei strain ENCL49790

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: H1Z82_RS09255
• Protein ID: WP_012906750.1
• Coordinates: 1924864..1925043 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H1Z82_RS09250
• Protein ID: WP_032634114.1
• Coordinates: 1924432..1924842 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1Z82_RS09230	1920268..1920819	+	552	WP_045345258.1	phage tail protein I	-
H1Z82_RS09235	1920822..1923377	+	2556	WP_181494105.1	phage tail protein	-
H1Z82_RS09240	1923379..1923801	+	423	WP_045342274.1	tail fiber assembly protein	-
H1Z82_RS09245	1923805..1924371	-	567	WP_045342272.1	serine acetyltransferase	-
H1Z82_RS09250	1924432..1924842	-	411	WP_032634114.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H1Z82_RS09255	1924864..1925043	-	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
H1Z82_RS09260	1925326..1926600	+	1275	WP_032619509.1	ATP-binding protein	-
H1Z82_RS09265	1926597..1927130	+	534	WP_032619510.1	glycosyltransferase family 2 protein	-
H1Z82_RS09270	1927735..1928661	+	927	WP_063436689.1	LysR family transcriptional regulator	-
H1Z82_RS09275	1928667..1929137	-	471	WP_045142345.1	hypothetical protein	-
H1Z82_RS09280	1929303..1930019	-	717	WP_017384431.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1884111..1930007	45896

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T168828 WP_012906750.1 NZ_CP059422:c1925043-1924864 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T168828 NZ_CP076243:c4629391-4629077 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14920.82 Da
• Isoelectric Point: 4.3170

>AT168828 WP_032634114.1 NZ_CP059422:c1924842-1924432 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYTGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Nucleotide

• Length: 411 bp

>AT168828 NZ_CP076243:c4629627-4629394 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4