Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1117101..1117721 Replicon chromosome
Accession NZ_CP059422
Organism Enterobacter hormaechei strain ENCL49790

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag H1Z82_RS05280 Protein ID WP_015571250.1
Coordinates 1117101..1117319 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag H1Z82_RS05285 Protein ID WP_006809850.1
Coordinates 1117347..1117721 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1Z82_RS05250 1113113..1113373 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
H1Z82_RS05255 1113376..1113516 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
H1Z82_RS05260 1113513..1114223 - 711 WP_181494061.1 GNAT family N-acetyltransferase -
H1Z82_RS05265 1114325..1115785 + 1461 WP_045142063.1 PLP-dependent aminotransferase family protein -
H1Z82_RS05270 1115757..1116224 - 468 WP_015571252.1 extracytoplasmic function sigma factor YlaC -
H1Z82_RS05275 1116341..1116892 - 552 WP_015571251.1 maltose O-acetyltransferase -
H1Z82_RS05280 1117101..1117319 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
H1Z82_RS05285 1117347..1117721 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
H1Z82_RS05290 1118232..1121378 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
H1Z82_RS05295 1121401..1122594 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T168825 WP_015571250.1 NZ_CP059422:c1117319-1117101 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T168825 NZ_CP076243:3679241-3679627 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT168825 WP_006809850.1 NZ_CP059422:c1117721-1117347 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT168825 NZ_CP076243:3679617-3679946 [Escherichia coli O157:H7]
ATGAGCAATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References