168822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 93633..95256 Replicon plasmid p48880_mcr
Accession NZ_CP059421
Organism Enterobacter hormaechei strain ENCL48880

Toxin (Protein)


Gene name hipA Uniprot ID C1IUI3
Locus tag H1D58_RS23725 Protein ID WP_000088044.1
Coordinates 93931..95256 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6M3PBR7
Locus tag H1D58_RS23720 Protein ID WP_012477377.1
Coordinates 93633..93926 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D58_RS23700 89432..89824 + 393 WP_000341066.1 hypothetical protein -
H1D58_RS23705 90483..91139 + 657 WP_000462754.1 trypsin-like serine protease -
H1D58_RS23710 91342..91839 + 498 WP_000340139.1 membrane protein -
H1D58_RS23715 91844..93232 + 1389 WP_012695445.1 hypothetical protein -
H1D58_RS23720 93633..93926 + 294 WP_012477377.1 helix-turn-helix transcriptional regulator Antitoxin
H1D58_RS23725 93931..95256 + 1326 WP_000088044.1 type II toxin-antitoxin system HipA family toxin Toxin
H1D58_RS23730 95317..95523 + 207 WP_000134171.1 hypothetical protein -
H1D58_RS23735 95624..96034 + 411 WP_000985909.1 hypothetical protein -
H1D58_RS23740 96047..96475 + 429 Protein_93 hypothetical protein -
H1D58_RS23745 96753..97757 - 1005 WP_000427623.1 IS110-like element IS4321 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaVIM-4 / aac(6')-Il / dfrA1 / aadA1 / qacE / sul1 / tet(A) / mcr-9 - 1..262616 262616


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50333.32 Da        Isoelectric Point: 6.5044

>T168822 WP_000088044.1 NZ_CP059421:93931-95256 [Enterobacter hormaechei]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T168822 NZ_CP076243:3046415-3046522 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10860.30 Da        Isoelectric Point: 10.3134

>AT168822 WP_012477377.1 NZ_CP059421:93633-93926 [Enterobacter hormaechei]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEGK
QTEEMLKSNSPARQEKW

Download         Length: 294 bp

>AT168822 NZ_CP076243:c3046362-3046301 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S1XXW1

Antitoxin

Source ID Structure
AlphaFold DB A0A6M3PBR7

References