Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3661691..3662358 Replicon chromosome
Accession NZ_CP059419
Organism Enterobacter hormaechei strain ENCL48880

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag H1D58_RS18720 Protein ID WP_181757101.1
Coordinates 3662029..3662358 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag H1D58_RS18715 Protein ID WP_181757100.1
Coordinates 3661691..3662002 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D58_RS18675 3656966..3657787 + 822 WP_181757097.1 DUF945 domain-containing protein -
H1D58_RS18680 3658004..3658705 + 702 WP_149335727.1 WYL domain-containing protein -
H1D58_RS18685 3658744..3659577 + 834 WP_181757098.1 hypothetical protein -
H1D58_RS18690 3659605..3660078 + 474 WP_128451208.1 hypothetical protein -
H1D58_RS18695 3660156..3660395 + 240 WP_032751322.1 DUF905 domain-containing protein -
H1D58_RS18700 3660492..3660950 + 459 WP_181757099.1 antirestriction protein -
H1D58_RS18705 3660966..3661442 + 477 WP_176982836.1 RadC family protein -
H1D58_RS18710 3661451..3661672 + 222 WP_100188781.1 DUF987 domain-containing protein -
H1D58_RS18715 3661691..3662002 + 312 WP_181757100.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H1D58_RS18720 3662029..3662358 + 330 WP_181757101.1 TA system toxin CbtA family protein Toxin
H1D58_RS18725 3662844..3663137 + 294 WP_180246312.1 hypothetical protein -
H1D58_RS18730 3663480..3664796 - 1317 WP_180246313.1 amidase -
H1D58_RS18735 3664851..3666146 - 1296 WP_180246314.1 histidinol dehydrogenase -
H1D58_RS18740 3666147..3666986 - 840 Protein_3373 ester cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3636019..3663137 27118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12320.34 Da        Isoelectric Point: 9.1228

>T168820 WP_181757101.1 NZ_CP059419:3662029-3662358 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYICAVDILRARRSTGLLKTDVK

Download         Length: 330 bp

>T168820 NZ_CP076243:c2788848-2788672 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11791.36 Da        Isoelectric Point: 6.2024

>AT168820 WP_181757100.1 NZ_CP059419:3661691-3662002 [Enterobacter hormaechei]
MSNITWGLQRDITPRLGARLVQERNQLHYLADRASITAKFSDDECLRLDETFPHFISQMEFMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGHVYIAIYPT

Download         Length: 312 bp

>AT168820 NZ_CP076243:c2788626-2788210 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References