168810

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1282938..1283559 Replicon chromosome
Accession NZ_CP059419
Organism Enterobacter hormaechei strain ENCL48880

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag H1D58_RS07475 Protein ID WP_015571250.1
Coordinates 1282938..1283156 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag H1D58_RS07480 Protein ID WP_006809850.1
Coordinates 1283185..1283559 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D58_RS07445 1278951..1279211 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
H1D58_RS07450 1279214..1279354 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
H1D58_RS07455 1279351..1280061 - 711 WP_163346922.1 GNAT family N-acetyltransferase -
H1D58_RS07460 1280164..1281624 + 1461 WP_163346924.1 PLP-dependent aminotransferase family protein -
H1D58_RS07465 1281596..1282063 - 468 WP_022647269.1 hypothetical protein -
H1D58_RS07470 1282180..1282731 - 552 WP_022647270.1 maltose O-acetyltransferase -
H1D58_RS07475 1282938..1283156 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
H1D58_RS07480 1283185..1283559 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
H1D58_RS07485 1284069..1287215 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
H1D58_RS07490 1287238..1288431 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T168810 WP_015571250.1 NZ_CP059419:c1283156-1282938 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T168810 NZ_CP076243:277213-277320 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT168810 WP_006809850.1 NZ_CP059419:c1283559-1283185 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT168810 NZ_CP076243:c277165-277099 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References