Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 144960..145576 Replicon chromosome
Accession NZ_CP059419
Organism Enterobacter hormaechei strain ENCL48880

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D58_RS02065 Protein ID WP_080339264.1
Coordinates 144960..145331 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag H1D58_RS02070 Protein ID WP_023298920.1
Coordinates 145334..145576 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D58_RS02050 142460..143362 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
H1D58_RS02055 143359..143994 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
H1D58_RS02060 143991..144920 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
H1D58_RS02065 144960..145331 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D58_RS02070 145334..145576 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
H1D58_RS02075 145776..146696 + 921 WP_163346823.1 alpha/beta hydrolase -
H1D58_RS02080 146705..147646 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
H1D58_RS02085 147691..148128 - 438 WP_063150747.1 D-tyrosyl-tRNA(Tyr) deacylase -
H1D58_RS02090 148125..149006 - 882 WP_023298923.1 virulence factor BrkB family protein -
H1D58_RS02095 149000..149599 - 600 WP_003861947.1 glucose-1-phosphatase -
H1D58_RS02100 149718..150518 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T168809 WP_080339264.1 NZ_CP059419:c145331-144960 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T168809 NZ_CP076242:52836-53141 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT168809 WP_023298920.1 NZ_CP059419:c145576-145334 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT168809 NZ_CP076242:52616-52834 [Escherichia coli O157:H7]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References