Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 251432..252171 Replicon plasmid p48880_VIM_4
Accession NZ_CP059418
Organism Enterobacter hormaechei strain ENCL48880

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag H1D58_RS01330 Protein ID WP_013087269.1
Coordinates 251686..252171 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag H1D58_RS01325 Protein ID WP_007869691.1
Coordinates 251432..251698 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D58_RS01305 246987..247757 + 771 WP_047721744.1 conjugal transfer protein TraX -
H1D58_RS01310 247772..248095 + 324 WP_015572034.1 hypothetical protein -
H1D58_RS01315 248073..248876 - 804 WP_032670854.1 DUF4225 domain-containing protein -
H1D58_RS01320 249766..250779 - 1014 WP_045418235.1 replication initiation protein -
H1D58_RS01325 251432..251698 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
H1D58_RS01330 251686..252171 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
H1D58_RS01335 252305..252733 + 429 Protein_266 DDE-type integrase/transposase/recombinase -
H1D58_RS01340 252683..252865 - 183 WP_045282329.1 hypothetical protein -
H1D58_RS01345 252953..254194 - 1242 WP_045282328.1 VWA domain-containing protein -
H1D58_RS01350 254622..255197 - 576 WP_020996162.1 TerD family protein -
H1D58_RS01355 255266..255844 - 579 WP_000116680.1 tellurium resistance membrane protein TerD -
H1D58_RS01360 255893..256933 - 1041 WP_000255079.1 tellurium resistance membrane protein TerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkB / mrkC / mrkD / mrkF / mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ 1..267489 267489
- flank IS/Tn - - 252527..252733 206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T168808 WP_013087269.1 NZ_CP059418:251686-252171 [Enterobacter hormaechei]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T168808 NZ_CP076242:2065-2340 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT168808 WP_007869691.1 NZ_CP059418:251432-251698 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT168808 NZ_CP076242:1781-2065 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References