168807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 106799..107442 Replicon plasmid p48880_VIM_4
Accession NZ_CP059418
Organism Enterobacter hormaechei strain ENCL48880

Toxin (Protein)


Gene name vagD Uniprot ID A0A155IU92
Locus tag H1D58_RS00580 Protein ID WP_000754567.1
Coordinates 107026..107442 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A155IUD1
Locus tag H1D58_RS00575 Protein ID WP_023293777.1
Coordinates 106799..107029 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D58_RS00550 102830..103840 + 1011 WP_015572055.1 RepB family plasmid replication initiator protein -
H1D58_RS00555 104084..104341 - 258 Protein_110 site-specific integrase -
H1D58_RS00560 104543..105319 - 777 WP_015572054.1 site-specific integrase -
H1D58_RS00565 105338..105868 - 531 WP_013087127.1 hypothetical protein -
H1D58_RS00570 105999..106289 - 291 WP_013087126.1 hypothetical protein -
H1D58_RS00575 106799..107029 + 231 WP_023293777.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H1D58_RS00580 107026..107442 + 417 WP_000754567.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D58_RS00585 107793..108761 - 969 WP_016151349.1 IS5 family transposase -
H1D58_RS00590 108921..109184 + 264 WP_001295708.1 hypothetical protein -
H1D58_RS00595 109378..109659 + 282 WP_023332908.1 helix-turn-helix domain-containing protein -
H1D58_RS00600 109694..110263 + 570 WP_023332907.1 small heat shock protein sHSP20 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkB / mrkC / mrkD / mrkF / mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ 1..267489 267489
- flank IS/Tn - - 107793..108761 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15108.61 Da        Isoelectric Point: 8.5403

>T168807 WP_000754567.1 NZ_CP059418:107026-107442 [Enterobacter hormaechei]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

>T168807 NZ_CP076241:c4982072-4981899 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8706.73 Da        Isoelectric Point: 4.4299

>AT168807 WP_023293777.1 NZ_CP059418:106799-107029 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAQREDVVSDEGRFDP

Download         Length: 231 bp

>AT168807 NZ_CP076241:c4982396-4982100 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155IU92

Antitoxin

Source ID Structure
AlphaFold DB A0A155IUD1

References