Detailed information of TA system TA168800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2943989..2944600
• Replicon: chromosome
• Accession: NZ_CP059414
• Organism: Enterobacter hormaechei strain ENCL48212

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: H1D56_RS15980
• Protein ID: WP_012906750.1
• Coordinates: 2943989..2944168 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H1D56_RS15985
• Protein ID: WP_032634114.1
• Coordinates: 2944190..2944600 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1D56_RS15955	2939013..2939729	+	717	WP_017384431.1	ABC transporter ATP-binding protein	-
H1D56_RS15960	2939895..2940365	+	471	WP_045142345.1	hypothetical protein	-
H1D56_RS15965	2940371..2941297	-	927	WP_063436689.1	LysR family transcriptional regulator	-
H1D56_RS15970	2941902..2942435	-	534	WP_032619510.1	glycosyltransferase family 2 protein	-
H1D56_RS15975	2942432..2943706	-	1275	WP_032619509.1	ATP-binding protein	-
H1D56_RS15980	2943989..2944168	+	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
H1D56_RS15985	2944190..2944600	+	411	WP_032634114.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H1D56_RS15990	2944661..2945227	+	567	WP_045342272.1	serine acetyltransferase	-
H1D56_RS15995	2945231..2945653	-	423	WP_045342274.1	tail fiber assembly protein	-
H1D56_RS16000	2945655..2948210	-	2556	WP_181494105.1	phage tail protein	-
H1D56_RS16005	2948213..2948764	-	552	WP_045345258.1	phage tail protein I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2939025..2986774	47749

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T168800 WP_012906750.1 NZ_CP059414:2943989-2944168 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T168800 NZ_CP076241:3542106-3542393 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14920.82 Da
• Isoelectric Point: 4.3170

>AT168800 WP_032634114.1 NZ_CP059414:2944190-2944600 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYTGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Nucleotide

• Length: 411 bp

>AT168800 NZ_CP076241:3541915-3542106 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4