Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2487509..2488248 Replicon chromosome
Accession NZ_CP059414
Organism Enterobacter hormaechei strain ENCL48212

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag H1D56_RS13830 Protein ID WP_003857133.1
Coordinates 2487509..2487994 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag H1D56_RS13835 Protein ID WP_003857131.1
Coordinates 2487982..2488248 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D56_RS13805 2482523..2483491 - 969 WP_022652343.1 IS5-like element IS903B family transposase -
H1D56_RS13810 2483566..2484198 + 633 WP_001567369.1 hypothetical protein -
H1D56_RS13815 2484227..2485629 - 1403 Protein_2375 ISNCY-like element ISKpn21 family transposase -
H1D56_RS13820 2485908..2486873 + 966 WP_032648329.1 hypothetical protein -
H1D56_RS13825 2486889..2487458 + 570 WP_032648331.1 hypothetical protein -
H1D56_RS13830 2487509..2487994 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
H1D56_RS13835 2487982..2488248 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
H1D56_RS13840 2488312..2489241 - 930 WP_045142163.1 LysR family transcriptional regulator -
H1D56_RS13845 2489371..2490759 + 1389 WP_045142139.1 MFS transporter -
H1D56_RS13850 2490781..2491776 - 996 WP_181494113.1 DUF2891 domain-containing protein -
H1D56_RS13855 2491786..2492772 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T168791 WP_003857133.1 NZ_CP059414:c2487994-2487509 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T168791 NZ_CP076241:760018-760332 [Escherichia coli O157:H7]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTTTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT168791 WP_003857131.1 NZ_CP059414:c2488248-2487982 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT168791 NZ_CP076241:760329-760745 [Escherichia coli O157:H7]
ATGATTGCGATTGCCGACATCTTGCATGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACATCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References