Detailed information of TA system TA168783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2607414..2608966
• Replicon: chromosome
• Accession: NZ_CP059400
• Organism: Legionella sp. PC1000

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FOLKNPGA_RS11430
• Protein ID: WP_182350029.1
• Coordinates: 2607659..2608966 (+)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FOLKNPGA_RS11425
• Protein ID: WP_182350028.1
• Coordinates: 2607414..2607665 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOLKNPGA_RS11405	2603118..2604830	+	1713	WP_182350024.1	ABC transporter ATP-binding protein/permease	-
FOLKNPGA_RS11410	2605027..2605320	+	294	WP_182350025.1	hypothetical protein	-
FOLKNPGA_RS11415	2605345..2606223	-	879	WP_182350026.1	DMT family transporter	-
FOLKNPGA_RS11420	2606505..2607206	+	702	WP_182350027.1	hypothetical protein	-
FOLKNPGA_RS11425	2607414..2607665	+	252	WP_182350028.1	helix-turn-helix domain-containing protein	Antitoxin
FOLKNPGA_RS11430	2607659..2608966	+	1308	WP_182350029.1	type II toxin-antitoxin system HipA family toxin	Toxin
FOLKNPGA_RS11435	2609119..2609994	+	876	WP_182350030.1	polysaccharide deacetylase family protein	-
FOLKNPGA_RS11440	2610086..2611300	-	1215	WP_182350031.1	murein transglycosylase A	-
FOLKNPGA_RS11445	2611483..2613603	-	2121	WP_182350032.1	FUSC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-64)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 50082.97 Da
• Isoelectric Point: 8.4315

>T168783 WP_182350029.1 NZ_CP059400:2607659-2608966 [Legionella sp. PC1000]
MVKKNQILYVLMNGILVGMLEKTSQGGLRFTYHQDWLNQTGARPISLSLPLVEQTYAGDVVYNFFDNLLPDNQQIRARIQ
ARFQIATSQPFDLLAGIGRDCVGAIQLITGPLAEFEKKIKYKPLTEQKIASILRNYQINPLGMSLEEKDFRISIAGAQEK
TAFLYHENQWCEPLQETPTTHIFKLPIGIIAHQQMDLRDSCENEWLCSLLAKSYGLPAADCEILHFEEIKVLSVKRFDRR
LSRDKSWIMRLPQEDLCQALGVSYNIKYQSDGGPGIKEIMQVLLGSAHPLLDRDMFYRAQVFFWLIAGIDGHAKNFSLFI
EPEGKYRLTPLYDIMSAYPLIKKRQLQIQKIKMAMALKGKNNHYHWHTLQRRHFIDTAKETSYSPERAEIILNEMLEQTD
SVIQEVSKKLPSSFPNSISEPIFEGLRKTKQKLEQ

Nucleotide

• Length: 1308 bp

>T168783 NZ_CP076239:2066-2341 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9343.90 Da
• Isoelectric Point: 10.7837

>AT168783 WP_182350028.1 NZ_CP059400:2607414-2607665 [Legionella sp. PC1000]
MLIHSSLELALLIKNQRKKLKLSQAEVAALVGLKQKTISAIENNPENMRLSTLFRILSALGLDLKISAKSQSNRATNQWN
DEW

Nucleotide

• Length: 252 bp

>AT168783 NZ_CP076239:1782-2066 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA