Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 864454..864988 Replicon chromosome
Accession NZ_CP059400
Organism Legionella sp. PC1000

Toxin (Protein)


Gene name relE Uniprot ID A0A7G3ZXI1
Locus tag FOLKNPGA_RS03780 Protein ID WP_058441828.1
Coordinates 864707..864988 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G3ZXI0
Locus tag FOLKNPGA_RS03775 Protein ID WP_058441829.1
Coordinates 864454..864714 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOLKNPGA_RS03745 860594..860755 + 162 WP_010652816.1 hypothetical protein -
FOLKNPGA_RS03750 860828..861013 - 186 WP_131793442.1 hypothetical protein -
FOLKNPGA_RS03755 861284..862972 + 1689 WP_058442215.1 DUF3141 domain-containing protein -
FOLKNPGA_RS03760 862972..863256 + 285 WP_058442214.1 DUF2933 domain-containing protein -
FOLKNPGA_RS03765 863256..863915 + 660 WP_182352751.1 isoprenylcysteine carboxylmethyltransferase family protein -
FOLKNPGA_RS03770 863912..864151 + 240 WP_058441830.1 hypothetical protein -
FOLKNPGA_RS03775 864454..864714 + 261 WP_058441829.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOLKNPGA_RS03780 864707..864988 + 282 WP_058441828.1 type II toxin-antitoxin system YafQ family toxin Toxin
FOLKNPGA_RS03785 865158..865274 + 117 Protein_742 transposase -
FOLKNPGA_RS03790 865593..866057 - 465 WP_083500881.1 transporter -
FOLKNPGA_RS03795 866057..869272 - 3216 WP_058441827.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 837872..937610 99738


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11045.81 Da        Isoelectric Point: 9.1368

>T168782 WP_058441828.1 NZ_CP059400:864707-864988 [Legionella sp. PC1000]
MLELELATQFKRDLKKIVKQGKDRKLIDSIVGQLQREEPLHPKHQDHNLSGNWHGYRECHITPDWLLIYKVIKDECMQLL
RLSRTGSHSDLFK

Download         Length: 282 bp

>T168782 NZ_CP076237:c5068641-5068468 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9562.14 Da        Isoelectric Point: 9.0428

>AT168782 WP_058441829.1 NZ_CP059400:864454-864714 [Legionella sp. PC1000]
MSKAATINARIEPALKMQAEAILHKVGLSTAEAIRLFYSQVCLQNGLPFEVKIPNKKTLDAIKELESGKGERFKTMKDVW
DSIDNA

Download         Length: 261 bp

>AT168782 NZ_CP076237:c5068965-5068669 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G3ZXI1

Antitoxin

Source ID Structure
AlphaFold DB A0A7G3ZXI0

References