Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4714242..4714758 Replicon chromosome
Accession NZ_CP059391
Organism Klebsiella africana strain FF1003

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H1X61_RS22550 Protein ID WP_136030901.1
Coordinates 4714242..4714526 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H1X61_RS22555 Protein ID WP_136030903.1
Coordinates 4714516..4714758 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1X61_RS22525 4709716..4710024 - 309 WP_016947038.1 PTS sugar transporter subunit IIB -
H1X61_RS22530 4710109..4710231 + 123 WP_203033274.1 hypothetical protein -
H1X61_RS22535 4710285..4711028 + 744 WP_203033275.1 MurR/RpiR family transcriptional regulator -
H1X61_RS22540 4711386..4713524 + 2139 WP_203033276.1 anaerobic ribonucleoside-triphosphate reductase -
H1X61_RS22545 4713774..4714238 + 465 WP_203033277.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H1X61_RS22550 4714242..4714526 - 285 WP_136030901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1X61_RS22555 4714516..4714758 - 243 WP_136030903.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H1X61_RS22560 4714836..4716746 - 1911 WP_203033278.1 BglG family transcription antiterminator -
H1X61_RS22565 4716769..4717923 - 1155 WP_136030906.1 lactonase family protein -
H1X61_RS22570 4718223..4718963 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11152.03 Da        Isoelectric Point: 10.3787

>T168773 WP_136030901.1 NZ_CP059391:c4714526-4714242 [Klebsiella africana]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKAPGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T168773 NZ_CP076237:c3337074-3336700 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT168773 WP_136030903.1 NZ_CP059391:c4714758-4714516 [Klebsiella africana]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVTLDDL

Download         Length: 243 bp

>AT168773 NZ_CP076237:c3337495-3337121 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References