Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2654934..2656522 Replicon chromosome
Accession NZ_CP059391
Organism Klebsiella africana strain FF1003

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H1X61_RS12905 Protein ID WP_203032615.1
Coordinates 2654934..2656256 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H1X61_RS12910 Protein ID WP_136034491.1
Coordinates 2656256..2656522 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1X61_RS12890 2649990..2652491 + 2502 WP_203032612.1 fimbrial biogenesis outer membrane usher protein -
H1X61_RS12895 2652479..2653483 + 1005 WP_203032613.1 type 1 fimbrial protein -
H1X61_RS12900 2653625..2654917 + 1293 WP_203032614.1 glycoside hydrolase family 10 protein -
H1X61_RS12905 2654934..2656256 - 1323 WP_203032615.1 type II toxin-antitoxin system HipA family toxin Toxin
H1X61_RS12910 2656256..2656522 - 267 WP_136034491.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
H1X61_RS12915 2656788..2657114 - 327 WP_136034202.1 hydroxyisourate hydrolase -
H1X61_RS12920 2657111..2657611 - 501 WP_136034200.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
H1X61_RS12925 2657589..2658968 - 1380 WP_136034198.1 purine permease -
H1X61_RS12930 2659313..2660467 + 1155 WP_203032616.1 FAD-dependent urate hydroxylase HpxO -
H1X61_RS12935 2660448..2661371 - 924 WP_136034194.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49390.63 Da        Isoelectric Point: 7.2493

>T168770 WP_203032615.1 NZ_CP059391:c2656256-2654934 [Klebsiella africana]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEALRWQTLDETQLTSLLTAYQSDIPLGMITDQDDFRISVAGAQEKTAL
LRMGDHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLTLARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAMMSFLLGSSEALKDRNDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFMATAKAVNFPREQMLAILQEFAERVP
QTIESARRTLPADFSTHVWQAITENVLKLHARLQQGLQAL

Download         Length: 1323 bp

>T168770 NZ_CP076237:2920968-2921123 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9909.27 Da        Isoelectric Point: 8.5912

>AT168770 WP_136034491.1 NZ_CP059391:c2656522-2656256 [Klebsiella africana]
MNSPQIYSPVQLASYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT168770 NZ_CP076237:c2920956-2920898 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References