Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808063..808720 Replicon chromosome
Accession NZ_CP059391
Organism Klebsiella africana strain FF1003

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag H1X61_RS03965 Protein ID WP_002916310.1
Coordinates 808310..808720 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H1X61_RS03960 Protein ID WP_002916312.1
Coordinates 808063..808329 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1X61_RS03935 803129..804562 - 1434 WP_136029134.1 6-phospho-beta-glucosidase BglA -
H1X61_RS03940 804681..805409 - 729 WP_136029428.1 MurR/RpiR family transcriptional regulator -
H1X61_RS03945 805460..805771 + 312 WP_136029136.1 N(4)-acetylcytidine aminohydrolase -
H1X61_RS03950 805935..806594 + 660 WP_061153356.1 hemolysin III family protein -
H1X61_RS03955 806834..807817 - 984 WP_136029139.1 tRNA-modifying protein YgfZ -
H1X61_RS03960 808063..808329 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H1X61_RS03965 808310..808720 + 411 WP_002916310.1 protein YgfX Toxin
H1X61_RS03970 808727..809248 - 522 WP_004144730.1 flavodoxin FldB -
H1X61_RS03975 809349..810245 + 897 WP_203033638.1 site-specific tyrosine recombinase XerD -
H1X61_RS03980 810268..810981 + 714 WP_136029141.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H1X61_RS03985 810987..812720 + 1734 WP_203033639.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T168760 WP_002916310.1 NZ_CP059391:808310-808720 [Klebsiella africana]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T168760 NZ_CP076237:408100-408627 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT168760 WP_002916312.1 NZ_CP059391:808063-808329 [Klebsiella africana]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT168760 NZ_CP076237:407827-408093 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References