Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 292319..292950 Replicon chromosome
Accession NZ_CP059391
Organism Klebsiella africana strain FF1003

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H1X61_RS01330 Protein ID WP_136033797.1
Coordinates 292319..292594 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H1X61_RS01335 Protein ID WP_080882890.1
Coordinates 292591..292950 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1X61_RS01310 287556..287891 + 336 WP_002921203.1 universal stress protein UspB -
H1X61_RS01315 287951..289447 - 1497 WP_025710729.1 inorganic phosphate transporter PitA -
H1X61_RS01320 289677..290870 + 1194 WP_203033525.1 NAD(P)/FAD-dependent oxidoreductase -
H1X61_RS01325 290910..291923 - 1014 WP_136033799.1 magnesium transporter -
H1X61_RS01330 292319..292594 + 276 WP_136033797.1 type II toxin-antitoxin system HicA family toxin Toxin
H1X61_RS01335 292591..292950 + 360 WP_080882890.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1X61_RS01340 292978..293379 - 402 WP_004181488.1 nickel-responsive transcriptional regulator NikR -
H1X61_RS01345 293367..294158 - 792 WP_203033526.1 nickel import ATP-binding protein NikE -
H1X61_RS01350 294155..294919 - 765 WP_136033793.1 nickel import ATP-binding protein NikD -
H1X61_RS01355 294919..295752 - 834 WP_203033527.1 nickel ABC transporter permease subunit NikC -
H1X61_RS01360 295749..296693 - 945 WP_136033789.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10270.90 Da        Isoelectric Point: 10.3164

>T168758 WP_136033797.1 NZ_CP059391:292319-292594 [Klebsiella africana]
MEQQVLSLRNKQRQTLEQLFKIPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T168758 NZ_CP076237:283227-283334 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13286.00 Da        Isoelectric Point: 4.4605

>AT168758 WP_080882890.1 NZ_CP059391:292591-292950 [Klebsiella africana]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKMKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLSERLKQA

Download         Length: 360 bp

>AT168758 NZ_CP076237:c283179-283113 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References