Detailed information of TA system TA168755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 3296471..3297055
• Replicon: chromosome
• Accession: NZ_CP059386
• Organism: Acinetobacter baumannii strain 36-1512

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: N9JY46
• Locus tag: H0S62_RS16405
• Protein ID: WP_000286963.1
• Coordinates: 3296753..3297055 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: H0S62_RS16400
• Protein ID: WP_000985610.1
• Coordinates: 3296471..3296752 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0S62_RS16360	3292105..3292563	+	459	WP_031953687.1	hypothetical protein	-
H0S62_RS16365	3292520..3293047	-	528	Protein_3175	IS256 family transposase	-
H0S62_RS16370	3293107..3294326	+	1220	WP_087486619.1	IS3-like element ISAba19 family transposase	-
H0S62_RS16375	3294366..3294518	-	153	Protein_3177	IS256 family transposase	-
H0S62_RS16380	3294783..3295043	+	261	WP_079377198.1	AraC family transcriptional regulator	-
H0S62_RS16385	3295139..3295429	-	291	WP_031953691.1	putative addiction module antidote protein	-
H0S62_RS16390	3295431..3295727	-	297	WP_004647749.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H0S62_RS16395	3295836..3296363	-	528	WP_002124964.1	plasmid pRiA4b ORF-3 family protein	-
H0S62_RS16400	3296471..3296752	-	282	WP_000985610.1	putative addiction module antidote protein	Antitoxin
H0S62_RS16405	3296753..3297055	-	303	WP_000286963.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H0S62_RS16410	3297247..3298068	+	822	WP_004796770.1	GIY-YIG nuclease family protein	-
H0S62_RS16415	3298157..3298552	+	396	WP_002059245.1	transposase family protein	-
H0S62_RS16420	3298675..3299894	+	1220	WP_087486619.1	IS3-like element ISAba19 family transposase	-
H0S62_RS16425	3299986..3300282	+	297	WP_107114744.1	transposase	-
H0S62_RS16430	3300500..3301093	-	594	WP_031953651.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3282746..3313611	30865
	-	inside	Prophage	-	-	3291131..3364719	73588
	-	inside	IScluster/Tn	-	-	3291131..3312602	21471

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-91)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11545.02 Da
• Isoelectric Point: 4.6838

>T168755 WP_000286963.1 NZ_CP059386:c3297055-3296753 [Acinetobacter baumannii]
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Nucleotide

• Length: 303 bp

>T168755 NZ_CP076235:c4857102-4856752 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10109.67 Da
• Isoelectric Point: 8.0018

>AT168755 WP_000985610.1 NZ_CP059386:c3296752-3296471 [Acinetobacter baumannii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Nucleotide

• Length: 282 bp

>AT168755 NZ_CP076235:c4857347-4857096 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A836MGN2