Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 1447609..1448122 Replicon chromosome
Accession NZ_CP059386
Organism Acinetobacter baumannii strain 36-1512

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2L2M0A2
Locus tag H0S62_RS07100 Protein ID WP_000203952.1
Coordinates 1447609..1447872 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S7WSW9
Locus tag H0S62_RS07105 Protein ID WP_000557943.1
Coordinates 1447859..1448122 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0S62_RS07070 1443698..1445128 + 1431 WP_000178999.1 amino acid permease -
H0S62_RS07075 1445186..1445530 - 345 Protein_1360 LysR family transcriptional regulator -
H0S62_RS07085 1446862..1447179 - 318 Protein_1362 LysR family transcriptional regulator -
H0S62_RS07090 1447313..1447411 + 99 Protein_1363 IS5/IS1182 family transposase -
H0S62_RS07095 1447443..1447550 - 108 Protein_1364 transposase domain-containing protein -
H0S62_RS07100 1447609..1447872 - 264 WP_000203952.1 Txe/YoeB family addiction module toxin Toxin
H0S62_RS07105 1447859..1448122 - 264 WP_000557943.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H0S62_RS07110 1448538..1451885 + 3348 WP_025467233.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10664.10 Da        Isoelectric Point: 8.4894

>T168753 WP_000203952.1 NZ_CP059386:c1447872-1447609 [Acinetobacter baumannii]
MTSRNVEWTENAWDEYIYWQTQDKKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
IQCRFHY

Download         Length: 264 bp

>T168753 NZ_CP076235:c4609342-4609028 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9841.04 Da        Isoelectric Point: 5.5940

>AT168753 WP_000557943.1 NZ_CP059386:c1448122-1447859 [Acinetobacter baumannii]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Download         Length: 264 bp

>AT168753 NZ_CP076235:c4609578-4609345 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L2M0A2

Antitoxin

Source ID Structure
AlphaFold DB S7WSW9

References