Detailed information of TA system TA168752

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 865412..866053
• Replicon: chromosome
• Accession: NZ_CP059386
• Organism: Acinetobacter baumannii strain 36-1512

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2S4T466
• Locus tag: H0S62_RS04225
• Protein ID: WP_000607071.1
• Coordinates: 865412..865801 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: H0S62_RS04230
• Protein ID: WP_171059649.1
• Coordinates: 865808..866053 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0S62_RS04205	860781..862835	+	2055	WP_005134658.1	M3 family metallopeptidase	-
H0S62_RS04210	862876..863085	+	210	WP_000745523.1	YheV family putative metal-binding protein	-
H0S62_RS04215	863097..863540	+	444	WP_005134656.1	hypothetical protein	-
H0S62_RS04220	863557..864642	-	1086	WP_181631164.1	hypothetical protein	-
H0S62_RS04225	865412..865801	-	390	WP_000607071.1	membrane protein	Toxin
H0S62_RS04230	865808..866053	-	246	WP_171059649.1	succinate dehydrogenase assembly factor 2	Antitoxin
H0S62_RS04235	866253..867425	+	1173	WP_001190557.1	acyl-CoA dehydrogenase family protein	-
H0S62_RS04240	867472..868962	-	1491	WP_005134653.1	NAD(P)/FAD-dependent oxidoreductase	-
H0S62_RS04245	869144..869521	-	378	WP_001216380.1	50S ribosomal protein L17	-
H0S62_RS04250	869540..870547	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15649.98 Da
• Isoelectric Point: 10.4623

>T168752 WP_000607071.1 NZ_CP059386:c865801-865412 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T168752 NZ_CP076235:c4371622-4371224 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9856.29 Da
• Isoelectric Point: 4.9108

>AT168752 WP_171059649.1 NZ_CP059386:c866053-865808 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKAEPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT168752 NZ_CP076235:c4371918-4371625 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A2S4T466