Detailed information of TA system TA168750

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 238208..238820
• Replicon: chromosome
• Accession: NZ_CP059383
• Organism: Streptococcus agalactiae strain BJ01

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: H1A19_RS01390
• Protein ID: WP_000384859.1
• Coordinates: 238208..238543 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: H1A19_RS01395
• Protein ID: WP_000259017.1
• Coordinates: 238533..238820 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1A19_RS01365	233406..234047	+	642	WP_000591145.1	hypothetical protein	-
H1A19_RS01370	234347..235222	+	876	WP_000421237.1	hypothetical protein	-
H1A19_RS01375	235258..235692	+	435	WP_001220482.1	hypothetical protein	-
H1A19_RS01380	236009..237265	+	1257	WP_000122836.1	plasmid recombination protein	-
H1A19_RS01385	237433..237903	+	471	WP_000130119.1	hypothetical protein	-
H1A19_RS01390	238208..238543	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H1A19_RS01395	238533..238820	-	288	WP_000259017.1	hypothetical protein	Antitoxin
H1A19_RS01400	239327..239617	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
H1A19_RS01405	239719..240126	+	408	WP_000749954.1	hypothetical protein	-
H1A19_RS01410	240126..240686	+	561	WP_001865562.1	hypothetical protein	-
H1A19_RS01415	240659..241339	+	681	WP_001865565.1	hypothetical protein	-
H1A19_RS01420	241324..241710	+	387	WP_000259069.1	hypothetical protein	-
H1A19_RS01425	241744..242025	+	282	WP_000052406.1	hypothetical protein	-
H1A19_RS01430	242868..243728	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	230238..239094	8856

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T168750 WP_000384859.1 NZ_CP059383:c238543-238208 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T168750 NZ_CP076235:3657650-3658036 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT168750 WP_000259017.1 NZ_CP059383:c238820-238533 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT168750 NZ_CP076235:3658026-3658355 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6