Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 448356..449009 Replicon chromosome
Accession NZ_CP059359
Organism Acinetobacter baumannii strain 2018TJAB1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag H1I74_RS02180 Protein ID WP_000607077.1
Coordinates 448620..449009 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag H1I74_RS02175 Protein ID WP_001288210.1
Coordinates 448356..448613 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1I74_RS02155 443872..444879 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
H1I74_RS02160 444898..445275 + 378 WP_001216380.1 50S ribosomal protein L17 -
H1I74_RS02165 445457..446947 + 1491 WP_000415125.1 NAD(P)/FAD-dependent oxidoreductase -
H1I74_RS02170 446996..448168 - 1173 WP_001190542.1 acyl-CoA dehydrogenase family protein -
H1I74_RS02175 448356..448613 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
H1I74_RS02180 448620..449009 + 390 WP_000607077.1 membrane protein Toxin
H1I74_RS02185 449779..450864 + 1086 WP_000049106.1 hypothetical protein -
H1I74_RS02190 450942..451508 + 567 WP_000651538.1 rhombosortase -
H1I74_RS02195 451696..453891 + 2196 WP_001158906.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T168746 WP_000607077.1 NZ_CP059359:448620-449009 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T168746 NZ_CP076235:3024794-3024901 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT168746 WP_001288210.1 NZ_CP059359:448356-448613 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT168746 NZ_CP076235:c3024741-3024680 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References