Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 468179..468832 Replicon chromosome
Accession NZ_CP059357
Organism Acinetobacter baumannii strain 2018HLJAB2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag H1I67_RS02240 Protein ID WP_000607077.1
Coordinates 468443..468832 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag H1I67_RS02235 Protein ID WP_001288210.1
Coordinates 468179..468436 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1I67_RS02215 463695..464702 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
H1I67_RS02220 464721..465098 + 378 WP_001216380.1 50S ribosomal protein L17 -
H1I67_RS02225 465280..466770 + 1491 WP_000415125.1 NAD(P)/FAD-dependent oxidoreductase -
H1I67_RS02230 466819..467991 - 1173 WP_001190542.1 acyl-CoA dehydrogenase family protein -
H1I67_RS02235 468179..468436 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
H1I67_RS02240 468443..468832 + 390 WP_000607077.1 membrane protein Toxin
H1I67_RS02245 469602..470687 + 1086 WP_000049106.1 hypothetical protein -
H1I67_RS02250 470765..471331 + 567 WP_000651538.1 rhombosortase -
H1I67_RS02255 471519..473714 + 2196 WP_001158906.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T168745 WP_000607077.1 NZ_CP059357:468443-468832 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T168745 NZ_CP076235:3024258-3024365 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT168745 WP_001288210.1 NZ_CP059357:468179-468436 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT168745 NZ_CP076235:c3024210-3024151 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References