Detailed information of TA system TA168744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1284348..1284999
• Replicon: chromosome
• Accession: NZ_CP059356
• Organism: Acinetobacter baumannii strain 2018HBAB1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: H1I68_RS06330
• Protein ID: WP_000838146.1
• Coordinates: 1284348..1284530 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: H1I68_RS06335
• Protein ID: WP_000966689.1
• Coordinates: 1284595..1284999 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1I68_RS06285	1279605..1280270	+	666	WP_038337351.1	stress-responsive nuclear envelope protein	-
H1I68_RS06290	1280275..1280664	+	390	WP_000008492.1	hypothetical protein	-
H1I68_RS06295	1280666..1281034	+	369	WP_000524231.1	hypothetical protein	-
H1I68_RS06300	1281043..1281447	+	405	WP_000248324.1	hypothetical protein	-
H1I68_RS06305	1281419..1281787	+	369	WP_000539752.1	hypothetical protein	-
H1I68_RS06310	1281789..1282187	+	399	WP_001132270.1	hypothetical protein	-
H1I68_RS06315	1282189..1282401	+	213	WP_000121166.1	hypothetical protein	-
H1I68_RS06320	1282509..1283438	+	930	WP_000094300.1	hypothetical protein	-
H1I68_RS06325	1283483..1284016	+	534	WP_001185622.1	hypothetical protein	-
H1I68_RS06330	1284348..1284530	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
H1I68_RS06335	1284595..1284999	+	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H1I68_RS06340	1285080..1285481	+	402	WP_000720591.1	hypothetical protein	-
H1I68_RS06345	1285542..1289507	+	3966	WP_000191304.1	tape measure protein	-
H1I68_RS06350	1289625..1289966	+	342	WP_001281459.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	blaADC-25	bauE / bauB / bauA / basC / basD / entE / basF / basG / barA / barB / basH / basI / basJ	1212977..1322508	109531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T168744 WP_000838146.1 NZ_CP059356:1284348-1284530 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T168744 NZ_CP076235:c2767228-2767052 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT168744 WP_000966689.1 NZ_CP059356:1284595-1284999 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT168744 NZ_CP076235:c2767006-2766590 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8