Detailed information of TA system TA168736

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 448374..449027
• Replicon: chromosome
• Accession: NZ_CP059350
• Organism: Acinetobacter baumannii strain 2018BJAB2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: H1I76_RS02180
• Protein ID: WP_000607077.1
• Coordinates: 448638..449027 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: H1I76_RS02175
• Protein ID: WP_001288210.1
• Coordinates: 448374..448631 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1I76_RS02155	443890..444897	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
H1I76_RS02160	444916..445293	+	378	WP_001216380.1	50S ribosomal protein L17	-
H1I76_RS02165	445475..446965	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
H1I76_RS02170	447014..448186	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
H1I76_RS02175	448374..448631	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
H1I76_RS02180	448638..449027	+	390	WP_000607077.1	membrane protein	Toxin
H1I76_RS02185	449797..450882	+	1086	WP_000049106.1	hypothetical protein	-
H1I76_RS02190	450960..451526	+	567	WP_000651538.1	rhombosortase	-
H1I76_RS02195	451714..453909	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T168736 WP_000607077.1 NZ_CP059350:448638-449027 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T168736 NZ_CP076235:c451210-450725 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT168736 WP_001288210.1 NZ_CP059350:448374-448631 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT168736 NZ_CP076235:c451479-451201 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7