Detailed information of TA system TA168733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3777773..3778412
• Replicon: chromosome
• Accession: NZ_CP059348
• Organism: Providencia rettgeri strain ZG2016M39-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H0913_RS17375
• Protein ID: WP_154603060.1
• Coordinates: 3777773..3778180 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H0913_RS17380
• Protein ID: WP_181478843.1
• Coordinates: 3778173..3778412 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0913_RS17345	3773363..3774691	-	1329	WP_181477678.1	N-acetylmuramoyl-L-alanine amidase AmiB	-
H0913_RS17350	3774706..3775170	-	465	WP_154638081.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-
H0913_RS17355	3775385..3776542	+	1158	WP_181477679.1	tRNA epoxyqueuosine(34) reductase QueG	-
H0913_RS17375	3777773..3778180	-	408	WP_154603060.1	tRNA(fMet)-specific endonuclease VapC	Toxin
H0913_RS17380	3778173..3778412	-	240	WP_181478843.1	antitoxin	Antitoxin
H0913_RS17385	3778499..3779041	-	543	WP_036948917.1	oligoribonuclease	-
H0913_RS17390	3779179..3780231	+	1053	WP_181477680.1	small ribosomal subunit biogenesis GTPase RsgA	-
H0913_RS17395	3780376..3781269	+	894	WP_181477681.1	phosphatidylserine decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15162.45 Da
• Isoelectric Point: 7.3226

>T168733 WP_154603060.1 NZ_CP059348:c3778180-3777773 [Providencia rettgeri]
MIKYLLDTNIIIFTIKRRPAALLPKFNQHADQLAISTITLAELVFGAEKSMNPERNLAVVNDFVSRLCVLPYDEAAACHY
GDIRANLEKQGKKIGENDLHIAAHARSKGLIVVTNNTREFERVDGLRLEDWVTSS

Nucleotide

• Length: 408 bp

>T168733 NZ_CP076235:277213-277320 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9199.38 Da
• Isoelectric Point: 5.0774

>AT168733 WP_181478843.1 NZ_CP059348:c3778412-3778173 [Providencia rettgeri]
ILHSKVFMSNRTQNVRLPAELRFPDDVKEVTVRMKGKERIITPLQNTWDSFFLTETSATDDFLVSRAEQVPTPRESFDD

Nucleotide

• Length: 240 bp

>AT168733 NZ_CP076235:c277165-277099 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT