Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1659299..1660093 Replicon chromosome
Accession NZ_CP059348
Organism Providencia rettgeri strain ZG2016M39-3

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag H0913_RS07480 Protein ID WP_181478381.1
Coordinates 1659299..1659820 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag H0913_RS07485 Protein ID WP_181478383.1
Coordinates 1659821..1660093 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0913_RS07450 1655485..1656324 + 840 WP_154604179.1 chemotaxis protein-glutamate O-methyltransferase -
H0913_RS07455 1656321..1657388 + 1068 WP_154604178.1 chemotaxis response regulator protein-glutamate methylesterase -
H0913_RS07460 1657431..1657823 + 393 WP_036951481.1 chemotaxis response regulator CheY -
H0913_RS07465 1657848..1658492 + 645 WP_154604177.1 protein phosphatase CheZ -
H0913_RS07470 1658610..1658919 - 310 Protein_1449 CcdB family protein -
H0913_RS07475 1658919..1659155 - 237 WP_154604175.1 type II toxin-antitoxin system CcdA family antitoxin -
H0913_RS07480 1659299..1659820 - 522 WP_181478381.1 GNAT family N-acetyltransferase Toxin
H0913_RS07485 1659821..1660093 - 273 WP_181478383.1 DUF1778 domain-containing protein Antitoxin
H0913_RS07490 1660540..1660887 - 348 WP_154604173.1 HNH nuclease YajD -
H0913_RS07495 1661172..1662323 + 1152 WP_181478385.1 flagellar type III secretion system protein FlhB -
H0913_RS07500 1662316..1664412 + 2097 WP_154604172.1 flagellar biosynthesis protein FlhA -
H0913_RS07505 1664661..1664816 + 156 WP_154604171.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-149)

Antitoxin

Vibrio phage ICP1, Orf50

(3-89)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 20051.11 Da        Isoelectric Point: 8.0298

>T168731 WP_181478381.1 NZ_CP059348:c1659820-1659299 [Providencia rettgeri]
VKDFKIAMYSEEIDYDLTHFDCGEPYMNTFLTEHLKRQHKNQILRGYMLLTKEEKPRVMGYYTLSGSSFEKRMLPSRQRQ
IAVPYENAPSVTLGRLAIDKSIQRQGYGELLVVHAMRIVYQASHAVGIYGLFVEALNDKAKQFYLRLGFIQLTGDNADSF
FYPIKSIEALFDM

Download         Length: 522 bp

>T168731 NZ_CP076234:2054-2329 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10367.80 Da        Isoelectric Point: 7.3211

>AT168731 WP_181478383.1 NZ_CP059348:c1660093-1659821 [Providencia rettgeri]
MLAPKTKRIDLRLNEEDKNLIEEAAAITNLSISQFMISIASERASEIVNHHRRLILNEHSWNLVQNAINNPPTVNNRLKQ
VAKRLQDTEE

Download         Length: 273 bp

>AT168731 NZ_CP076234:1770-2054 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References