Detailed information of TA system TA168726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 3987753..3988485
• Replicon: chromosome
• Accession: NZ_CP059347
• Organism: Providencia rettgeri strain 2353217

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H0912_RS18035
• Protein ID: WP_166264489.1
• Coordinates: 3988072..3988485 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H0912_RS18030
• Protein ID: WP_102138206.1
• Coordinates: 3987753..3988082 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0912_RS18015	3983722..3984693	-	972	WP_102138203.1	efflux RND transporter periplasmic adaptor subunit	-
H0912_RS18020	3985327..3987012	+	1686	WP_102138263.1	sensor histidine kinase	-
H0912_RS18025	3987032..3987748	+	717	WP_102138205.1	two-component system response regulator BtsR	-
H0912_RS18030	3987753..3988082	-	330	WP_102138206.1	helix-turn-helix domain-containing protein	Antitoxin
H0912_RS18035	3988072..3988485	-	414	WP_166264489.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H0912_RS18040	3988615..3990555	-	1941	WP_102138207.1	DEAD/DEAH family ATP-dependent RNA helicase	-
H0912_RS18045	3990726..3991592	-	867	WP_102138265.1	lipoprotein NlpI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (12-132)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-93)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15366.71 Da
• Isoelectric Point: 9.6258

>T168726 WP_166264489.1 NZ_CP059347:c3988485-3988072 [Providencia rettgeri]
MSTTWRVVVAFYKISSFKRSTKKINIKDKQLLKAANEVLQGFYEADLGSGVIKKRIAINGKGKSGGIRVIIFFKASHHLF
FADGWDKSNISSKGAKEIAEDELDAYKGLSRLFLSYTDDKIADLVLCNILEELTDEQ

Nucleotide

• Length: 414 bp

>T168726 NZ_CP076232:c5155200-5154793 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12331.57 Da
• Isoelectric Point: 10.4252

>AT168726 WP_102138206.1 NZ_CP059347:c3988082-3987753 [Providencia rettgeri]
MSNKLENMLELAKELHNVDAAPESLVNDLERKVRARNINKKIKVIPMMSGAQIKQLRAQYGMSQATLALVLGMSKESVSK
WEREEKKPSGPALRMLHLIEQRGPEILII

Nucleotide

• Length: 330 bp

>AT168726 NZ_CP076232:c5155447-5155181 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA