Detailed information of TA system TA168725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 3980695..3981280
• Replicon: chromosome
• Accession: NZ_CP059347
• Organism: Providencia rettgeri strain 2353217

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H0912_RS17995
• Protein ID: WP_102138200.1
• Coordinates: 3980695..3981012 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4C3P0
• Locus tag: H0912_RS18000
• Protein ID: WP_004905876.1
• Coordinates: 3980993..3981280 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0912_RS17965	3976400..3976651	-	252	WP_102138194.1	DUF1471 domain-containing protein	-
H0912_RS17970	3976921..3977259	+	339	WP_102138195.1	GIY-YIG nuclease family protein	-
H0912_RS17975	3977232..3977735	-	504	WP_102138196.1	N-acetyltransferase	-
H0912_RS17980	3977729..3978253	-	525	WP_102138197.1	SCP2 domain-containing protein	-
H0912_RS17985	3978767..3979762	+	996	WP_102138198.1	U32 family peptidase	-
H0912_RS17990	3979780..3980655	+	876	WP_102138199.1	U32 family peptidase	-
H0912_RS17995	3980695..3981012	-	318	WP_102138200.1	type II toxin-antitoxin system YafQ family toxin	Toxin
H0912_RS18000	3980993..3981280	-	288	WP_004905876.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H0912_RS18005	3981411..3982565	-	1155	WP_102138201.1	ABC transporter permease	-
H0912_RS18010	3982565..3983710	-	1146	WP_102138202.1	ABC transporter permease	-
H0912_RS18015	3983722..3984693	-	972	WP_102138203.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (14-105)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-75)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12221.96 Da
• Isoelectric Point: 9.7799

>T168725 WP_102138200.1 NZ_CP059347:c3981012-3980695 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGSRELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Nucleotide

• Length: 318 bp

>T168725 NZ_CP076232:c5009717-5009382 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10763.44 Da
• Isoelectric Point: 5.8809

>AT168725 WP_004905876.1 NZ_CP059347:c3981280-3980993 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Nucleotide

• Length: 288 bp

>AT168725 NZ_CP076232:c5009965-5009717 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A345M0A6