Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3822647..3823443 Replicon chromosome
Accession NZ_CP059347
Organism Providencia rettgeri strain 2353217

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag H0912_RS17305 Protein ID WP_102138079.1
Coordinates 3822647..3823159 (-) Length 171 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag H0912_RS17310 Protein ID WP_102138080.1
Coordinates 3823156..3823443 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0912_RS17290 3818699..3819670 - 972 WP_102138076.1 DNA-binding transcriptional regulator DsdC -
H0912_RS17295 3819887..3821224 + 1338 WP_102138077.1 D-serine transporter DsdX -
H0912_RS17300 3821237..3822571 + 1335 WP_102138078.1 D-serine ammonia-lyase -
H0912_RS17305 3822647..3823159 - 513 WP_102138079.1 GNAT family N-acetyltransferase Toxin
H0912_RS17310 3823156..3823443 - 288 WP_102138080.1 DUF1778 domain-containing protein Antitoxin
H0912_RS17315 3823692..3824747 - 1056 WP_102138081.1 osmoprotectant NAGGN system M42 family peptidase -
H0912_RS17320 3824752..3825522 - 771 WP_102138082.1 FadR family transcriptional regulator -
H0912_RS17325 3825553..3826356 - 804 WP_102138083.1 ABC transporter ATP-binding protein -
H0912_RS17330 3826356..3828170 - 1815 WP_102138084.1 dipeptide/oligopeptide/nickel ABC transporter permease/ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(35-147)

Antitoxin

Vibrio phage ICP1, Orf50

(14-87)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18369.25 Da        Isoelectric Point: 9.8443

>T168724 WP_102138079.1 NZ_CP059347:c3823159-3822647 [Providencia rettgeri]
MTLKLTAPEPLKTGHLLEGFSSGEEALDLWLKNRAMSYQNSGASRTFVTTSDNQVMGYYALSTGVVSTNQAAGRFRRNMP
SDIPVILLGRLAVDTRAKGLGVGRGLVKDACHRVIQASGLVGIRGVVVHALTDNAKRFYEHIGFVPSPLDSMMLMITLAD
LQFALGIHPN

Download         Length: 513 bp

>T168724 NZ_CP076232:c4187194-4187018 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10607.97 Da        Isoelectric Point: 4.8660

>AT168724 WP_102138080.1 NZ_CP059347:c3823443-3823156 [Providencia rettgeri]
MSTQNDVAVTRSSLNLRIKPEDKILIDRAANAVGKNRTEFVLEAARRAAEETLADLRVINVSAEVYQEFISQLDAAPSSN
EALRKTMMSKSPWEE

Download         Length: 288 bp

>AT168724 NZ_CP076232:c4186972-4186556 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References