Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2974530..2975077 Replicon chromosome
Accession NZ_CP059347
Organism Providencia rettgeri strain 2353217

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag H0912_RS13405 Protein ID WP_181489860.1
Coordinates 2974769..2975077 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag H0912_RS13400 Protein ID WP_102139589.1
Coordinates 2974530..2974769 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0912_RS13385 2969899..2970870 + 972 WP_181489859.1 Abi family protein -
H0912_RS13390 2971023..2973122 - 2100 WP_102139591.1 flagellar biosynthesis protein FlhA -
H0912_RS13395 2973115..2974266 - 1152 WP_102139590.1 flagellar type III secretion system protein FlhB -
H0912_RS13400 2974530..2974769 + 240 WP_102139589.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H0912_RS13405 2974769..2975077 + 309 WP_181489860.1 CcdB family protein Toxin
H0912_RS13410 2975093..2975650 + 558 WP_102139588.1 hypothetical protein -
H0912_RS13415 2975693..2975998 - 306 WP_102139587.1 helix-turn-helix domain-containing protein -
H0912_RS13420 2976086..2976724 - 639 WP_102139586.1 protein phosphatase CheZ -
H0912_RS13425 2976749..2977141 - 393 WP_004255705.1 chemotaxis response regulator CheY -
H0912_RS13430 2977183..2978250 - 1068 WP_102139585.1 chemotaxis response regulator protein-glutamate methylesterase -
H0912_RS13435 2978250..2979086 - 837 WP_102139584.1 chemotaxis protein-glutamate O-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11788.94 Da        Isoelectric Point: 7.8789

>T168723 WP_181489860.1 NZ_CP059347:2974769-2975077 [Providencia rettgeri]
MQYCLYQNREDTVKYPYLLDIQSNIIDILNTRLVIPLFDSRLVKKPLPVRLNPQLSINGQVFILMTHQMACVPLSLLGKE
IVDLTHQRDTIKHAVDLLINGF

Download         Length: 309 bp

>T168723 NZ_CP076232:c3842831-3842553 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9167.45 Da        Isoelectric Point: 9.0005

>AT168723 WP_102139589.1 NZ_CP059347:2974530-2974769 [Providencia rettgeri]
MNTTAQRMKKTVSVTVAPELYEQARQAKLNLSAILTCALQAELKRLEAQKWKNENREGFNELNRINEEHGLLSDKYKDF

Download         Length: 240 bp

>AT168723 NZ_CP076232:c3843024-3842833 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References