Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2434199..2435115 Replicon chromosome
Accession NZ_CP059347
Organism Providencia rettgeri strain 2353217

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag H0912_RS10765 Protein ID WP_102140346.1
Coordinates 2434657..2435115 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag H0912_RS10760 Protein ID WP_102140345.1
Coordinates 2434199..2434660 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0912_RS10720 2429212..2429826 + 615 WP_102140337.1 LysE family translocator -
H0912_RS10725 2429850..2430323 - 474 WP_166267453.1 NUDIX domain-containing protein -
H0912_RS10730 2430380..2430769 - 390 WP_102140339.1 cytidine deaminase -
H0912_RS10735 2430802..2431068 - 267 WP_166267457.1 GntR family transcriptional regulator -
H0912_RS10740 2431329..2431970 - 642 WP_102140341.1 leucine efflux protein LeuE -
H0912_RS10745 2432445..2433146 + 702 WP_102140342.1 AzlC family ABC transporter permease -
H0912_RS10750 2433143..2433457 + 315 WP_102140343.1 AzlD domain-containing protein -
H0912_RS10755 2433645..2434112 + 468 WP_102140344.1 DUF1456 family protein -
H0912_RS10760 2434199..2434660 + 462 WP_102140345.1 DUF2384 domain-containing protein Antitoxin
H0912_RS10765 2434657..2435115 + 459 WP_102140346.1 RES domain-containing protein Toxin
H0912_RS10770 2435116..2436006 - 891 WP_102140347.1 LysR family transcriptional regulator -
H0912_RS10775 2436048..2437007 - 960 WP_102140348.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
H0912_RS10780 2437112..2437534 - 423 WP_102140349.1 helix-turn-helix domain-containing protein -
H0912_RS10785 2437565..2438128 - 564 WP_102140350.1 GNAT family N-acetyltransferase -
H0912_RS10790 2438109..2439575 - 1467 WP_102140351.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2433143..2483941 50798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-95)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17153.77 Da        Isoelectric Point: 6.3188

>T168722 WP_102140346.1 NZ_CP059347:2434657-2435115 [Providencia rettgeri]
MILYRLVKSIFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDILLNQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPASTSTMDIGTTWLNNQDSLVLLIPSCIIPYEYNAIINPLHPQFQKAIRTVKPLDFSVDPRLA

Download         Length: 459 bp

>T168722 NZ_CP076232:3568211-3568314 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16968.38 Da        Isoelectric Point: 9.7275

>AT168722 WP_102140345.1 NZ_CP059347:2434199-2434660 [Providencia rettgeri]
MRNYIPTTPLQPAASASKPLWRHVGLPAERGIELTHYLRQGLSVSVLDNIQEWSGVSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Download         Length: 462 bp

>AT168722 NZ_CP076232:c3568352-3568081 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References