Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1009989..1010635 Replicon chromosome
Accession NZ_CP059347
Organism Providencia rettgeri strain 2353217

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag H0912_RS04445 Protein ID WP_102139052.1
Coordinates 1009989..1010192 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag H0912_RS04450 Protein ID WP_102139053.1
Coordinates 1010267..1010635 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0912_RS04420 1006087..1006425 + 339 WP_004905421.1 P-II family nitrogen regulator -
H0912_RS04425 1006475..1007722 + 1248 WP_181490144.1 ammonium transporter AmtB -
H0912_RS04430 1007862..1008731 - 870 WP_102139050.1 acyl-CoA thioesterase II -
H0912_RS04435 1008971..1009429 + 459 WP_181490048.1 YbaY family lipoprotein -
H0912_RS04445 1009989..1010192 - 204 WP_102139052.1 hemolysin expression modulator Hha Toxin
H0912_RS04450 1010267..1010635 - 369 WP_102139053.1 Hha toxicity modulator TomB Antitoxin
H0912_RS04455 1011164..1012534 - 1371 WP_102139054.1 murein transglycosylase D -
H0912_RS04460 1012616..1013371 - 756 WP_102139055.1 hydroxyacylglutathione hydrolase -
H0912_RS04465 1013412..1014146 + 735 WP_102139056.1 methyltransferase domain-containing protein -
H0912_RS04470 1014143..1014613 - 471 WP_102139057.1 ribonuclease HI -
H0912_RS04475 1014668..1015429 + 762 WP_102139069.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8121.44 Da        Isoelectric Point: 6.9770

>T168720 WP_102139052.1 NZ_CP059347:c1010192-1009989 [Providencia rettgeri]
MTKFDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T168720 NZ_CP076232:c2980495-2980388 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14033.99 Da        Isoelectric Point: 4.3849

>AT168720 WP_102139053.1 NZ_CP059347:c1010635-1010267 [Providencia rettgeri]
MDEYSPKKHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEVIDWEAMNQSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT168720 NZ_CP076232:2980543-2980602 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References