Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3219647..3220304 Replicon chromosome
Accession NZ_CP059345
Organism Providencia rettgeri strain 2055

Toxin (Protein)


Gene name cptA Uniprot ID A0A1J0E9L4
Locus tag H0907_RS14655 Protein ID WP_042845040.1
Coordinates 3219647..3220057 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1J0E9J6
Locus tag H0907_RS14660 Protein ID WP_042845042.1
Coordinates 3220038..3220304 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0907_RS14635 3215586..3217319 - 1734 WP_181468666.1 single-stranded-DNA-specific exonuclease RecJ -
H0907_RS14640 3217329..3218033 - 705 WP_042845413.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H0907_RS14645 3218055..3218957 - 903 WP_129466206.1 site-specific tyrosine recombinase XerD -
H0907_RS14650 3219075..3219593 + 519 WP_042845038.1 flavodoxin FldB -
H0907_RS14655 3219647..3220057 - 411 WP_042845040.1 protein YgfX Toxin
H0907_RS14660 3220038..3220304 - 267 WP_042845042.1 FAD assembly factor SdhE Antitoxin
H0907_RS14665 3220554..3221543 + 990 WP_181468667.1 tRNA-modifying protein YgfZ -
H0907_RS14670 3221555..3222175 + 621 WP_042845046.1 HD domain-containing protein -
H0907_RS14675 3222330..3223226 + 897 WP_048607912.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15461.25 Da        Isoelectric Point: 10.6538

>T168716 WP_042845040.1 NZ_CP059345:c3220057-3219647 [Providencia rettgeri]
VVLWKSNLSISWKTQFFSTCVHGAVGMFLLVAPWAPAHSMIWLPLLAVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWNIVKAPWLSRYGILLSLEALQGKQQKIHLWVAKDSVSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T168716 NZ_CP076232:c2319884-2319498 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10619.16 Da        Isoelectric Point: 4.8780

>AT168716 WP_042845042.1 NZ_CP059345:c3220304-3220038 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLTTNDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT168716 NZ_CP076232:c2319508-2319179 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E9L4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E9J6

References