Detailed information of TA system TA168715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2295572..2296491
• Replicon: chromosome
• Accession: NZ_CP059345
• Organism: Providencia rettgeri strain 2055

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A1J0E7D4
• Locus tag: H0907_RS10295
• Protein ID: WP_042843809.1
• Coordinates: 2295572..2296033 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H0907_RS10300
• Protein ID: WP_048607179.1
• Coordinates: 2296030..2296491 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0907_RS10270	2291074..2292534	+	1461	WP_042844339.1	AMP nucleosidase	-
H0907_RS10275	2292515..2293084	+	570	WP_042843815.1	GNAT family N-acetyltransferase	-
H0907_RS10280	2293141..2293563	+	423	WP_042843814.1	helix-turn-helix domain-containing protein	-
H0907_RS10285	2293670..2294629	+	960	WP_181469296.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
H0907_RS10290	2294673..2295563	+	891	WP_181469297.1	LysR family transcriptional regulator	-
H0907_RS10295	2295572..2296033	-	462	WP_042843809.1	RES domain-containing protein	Toxin
H0907_RS10300	2296030..2296491	-	462	WP_048607179.1	DUF2384 domain-containing protein	Antitoxin
H0907_RS10305	2296581..2297048	-	468	WP_042843807.1	DUF1456 family protein	-
H0907_RS10310	2297234..2297548	-	315	WP_042843806.1	AzlD domain-containing protein	-
H0907_RS10315	2297545..2298246	-	702	WP_048607181.1	AzlC family ABC transporter permease	-
H0907_RS10320	2298933..2299574	+	642	WP_048607183.1	leucine efflux protein LeuE	-
H0907_RS10325	2299634..2300092	-	459	WP_042843802.1	GNAT family N-acetyltransferase	-
H0907_RS10330	2300511..2300897	+	387	WP_048607185.1	cytidine deaminase	-
H0907_RS10335	2300921..2301385	+	465	WP_042843800.1	NUDIX domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (38-95)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 17499.99 Da
• Isoelectric Point: 6.4846

>T168715 WP_042843809.1 NZ_CP059345:c2296033-2295572 [Providencia rettgeri]
MILYRLIKSDFAHDAWSGQGARLYGGRWNHKGTPAIYTSTSISLAALEILVHINQDTVLNHFTLLSIEINDRYVMKLSVE
HLPDDWQRDPAPTSTMDIGTTWLTNQDSLALIVPSCIIPYEYNAIINPMHPQFQKVTQTIKPLDFAFDPRFNR

Nucleotide

• Length: 462 bp

>T168715 NZ_CP076232:c1864771-1864553 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17056.55 Da
• Isoelectric Point: 9.9812

>AT168715 WP_048607179.1 NZ_CP059345:c2296491-2296030 [Providencia rettgeri]
MRNYIPALPTQPATPPFKPLWRFAGLPAERGIELTHFLRQGLSVTVLDNIQEWSGISKSELLRISGINERNVARRRNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKSMASDWLNHPVKGLGHTRPIELIATESGALEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT168715 NZ_CP076232:c1865171-1864797 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A1J0E7D4