Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1044142..1044788 Replicon chromosome
Accession NZ_CP059345
Organism Providencia rettgeri strain 2055

Toxin (Protein)


Gene name Hha Uniprot ID A0A1J0E3F0
Locus tag H0907_RS04575 Protein ID WP_042846891.1
Coordinates 1044142..1044345 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1J0E3I4
Locus tag H0907_RS04580 Protein ID WP_042846890.1
Coordinates 1044420..1044788 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0907_RS04550 1040221..1040559 + 339 WP_181469088.1 P-II family nitrogen regulator -
H0907_RS04555 1040570..1041853 + 1284 WP_042846894.1 ammonium transporter AmtB -
H0907_RS04560 1041994..1042860 - 867 WP_042846893.1 acyl-CoA thioesterase II -
H0907_RS04565 1043100..1043558 + 459 WP_042846892.1 YbaY family lipoprotein -
H0907_RS04575 1044142..1044345 - 204 WP_042846891.1 hemolysin expression modulator Hha Toxin
H0907_RS04580 1044420..1044788 - 369 WP_042846890.1 Hha toxicity modulator TomB Antitoxin
H0907_RS04585 1045318..1046688 - 1371 WP_048608373.1 murein transglycosylase D -
H0907_RS04590 1046770..1047522 - 753 WP_048608371.1 hydroxyacylglutathione hydrolase -
H0907_RS04595 1047556..1048290 + 735 WP_042846887.1 methyltransferase domain-containing protein -
H0907_RS04600 1048287..1048757 - 471 WP_042846886.1 ribonuclease HI -
H0907_RS04605 1048812..1049573 + 762 WP_048608368.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T168714 WP_042846891.1 NZ_CP059345:c1044345-1044142 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

>T168714 NZ_CP076232:1605849-1606247 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14123.05 Da        Isoelectric Point: 4.3849

>AT168714 WP_042846890.1 NZ_CP059345:c1044788-1044420 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSAQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWETMNQNLVSVLDDDLKCLTSKT

Download         Length: 369 bp

>AT168714 NZ_CP076232:1605553-1605846 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E3I4

References