Detailed information of TA system TA168713

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 823002..824724
• Replicon: chromosome
• Accession: NZ_CP059345
• Organism: Providencia rettgeri strain 2055

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: D0FZT9
• Locus tag: H0907_RS03640
• Protein ID: WP_000356587.1
• Coordinates: 823786..824724 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: H0907_RS03635
• Protein ID: WP_048608544.1
• Coordinates: 823002..823793 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0907_RS03605	818675..818956	+	282	WP_000433889.1	type IV conjugative transfer system protein TraL	-
H0907_RS03610	818953..819579	+	627	WP_000667170.1	hypothetical protein	-
H0907_RS03615	819563..820459	+	897	WP_048608549.1	type-F conjugative transfer system secretin TraK	-
H0907_RS03620	820462..821751	+	1290	WP_085285719.1	TraB/VirB10 family protein	-
H0907_RS03625	821826..822398	+	573	WP_139175592.1	type IV conjugative transfer system lipoprotein TraV	-
H0907_RS03630	822395..822781	+	387	WP_048608546.1	hypothetical protein	-
H0907_RS03635	823002..823793	+	792	WP_048608544.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
H0907_RS03640	823786..824724	+	939	WP_000356587.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H0907_RS03645	824856..825548	+	693	WP_001228924.1	DsbC family protein	-
H0907_RS03650	825548..827947	+	2400	WP_048608542.1	type IV secretion system protein TraC	-
H0907_RS03655	827940..828287	+	348	WP_048608540.1	hypothetical protein	-
H0907_RS03660	828271..828783	+	513	WP_172689549.1	S26 family signal peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	ARR-3 / dfrA27 / aadA16 / qacE / sul1 / blaPER-1 / aph(3')-VIb / tet(C) / aadA6 / mph(A)	-	692162..898517	206355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-97)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35548.82 Da
• Isoelectric Point: 4.9081

>T168713 WP_000356587.1 NZ_CP059345:823786-824724 [Providencia rettgeri]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T168713 NZ_CP076232:1368151-1368465 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30100.44 Da
• Isoelectric Point: 9.3513

>AT168713 WP_048608544.1 NZ_CP059345:823002-823793 [Providencia rettgeri]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT168713 NZ_CP076232:1367915-1368148 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: A0A1U9VZ44