Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/COG1569-excise
Location 184740..185795 Replicon chromosome
Accession NZ_CP059343
Organism Kocuria varians strain 80

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CIB50_RS00855 Protein ID WP_094395018.1
Coordinates 185232..185795 (+) Length 188 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag CIB50_RS00850 Protein ID WP_094395016.1
Coordinates 184740..185225 (+) Length 162 a.a.

Genomic Context

CIB50_RS00840CIB50_RS00845CIB50_RS00850CIB50_RS00855CIB50_RS00870CIB50_RS00875CIB50_RS00835CIB50_RS00860CIB50_RS00865
Location: 181892..183316 (1425 bp)
Type: Others
Protein ID: WP_094395014.1
Location: 183411..184619 (1209 bp)
Type: Others
Protein ID: WP_094395238.1
Location: 184740..185225 (486 bp)
Type: Antitoxin
Protein ID: WP_094395016.1
Location: 185232..185795 (564 bp)
Type: Toxin
Protein ID: WP_094395018.1
Location: 187696..187977 (282 bp)
Type: Others
Protein ID: WP_094395021.1
Location: 188283..189491 (1209 bp)
Type: Others
Protein ID: WP_094395023.1
Location: 180108..181676 (1569 bp)
Type: Others
Protein ID: WP_094395012.1
Location: 185869..187017 (1149 bp)
Type: Others
Protein ID: WP_094395019.1
Location: 187061..187498 (438 bp)
Type: Others
Protein ID: WP_012397587.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CIB50_RS00835180108..181676-1569WP_094395012.1type I restriction-modification system subunit M-
CIB50_RS00840181892..183316+1425WP_094395014.1type I restriction endonuclease subunit R-
CIB50_RS00845183411..184619+1209WP_094395238.1DUF1624 domain-containing protein-
CIB50_RS00850184740..185225+486WP_094395016.1helix-turn-helix domain-containing proteinAntitoxin
CIB50_RS00855185232..185795+564WP_094395018.1PIN domain-containing proteinToxin
CIB50_RS00860185869..187017-1149WP_094395019.1PLP-dependent cysteine synthase family protein-
CIB50_RS00865187061..187498-438WP_012397587.1cytidine deaminase-
CIB50_RS00870187696..187977+282WP_094395021.1hypothetical protein-
CIB50_RS00875188283..189491+1209WP_094395023.1TAXI family TRAP transporter solute-binding subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN family, putative toxin-antitoxin system toxin component

(1-129)

Antitoxin

Helix-turn-helix domain, group 17

(82-129)


Sequences

Toxin        


Download         Length: 188 a.a.        Molecular weight: 20889.05 Da        Isoelectric Point: 5.3200

>T168709 WP_094395018.1 NZ_CP059343:185232-185795 [Kocuria varians]
MSFPVVLDACVLIPMPIADLLLRLATAKQFRPLWSDEILNEVERNLVKNLHKDPHSARRRVNAMRGFFPDALVENYESLV
PAMTNDPKDRHVLAAAVRSRAELIVTSNQKDFPTTALKPYDVAVRSPDDFLLDQLDLDPSTVVRIAEEVVADMRNPTITW
NGYLEGLARAGLPLFATELEKRTAGVG

Download         Length: 564 bp

>T168709 NZ_CP076232:c473332-472847 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 162 a.a.        Molecular weight: 17450.77 Da        Isoelectric Point: 7.0748

>AT168709 WP_094395016.1 NZ_CP059343:184740-185225 [Kocuria varians]
MTTAPLDRSTVAPTPAHEEELKALAAFLEAAPSAQGRGIPYLVSPTGATQQIPAEVYSLLTHVVDALANNRGVSVVPTNA
KLTTQQAADHLGISRPTLVKLLEQGDIPFTKVGRHRRVLLTDLIAYEERLEKTRREGLRQATHEAANHGTYFDIPADPAT
R

Download         Length: 486 bp

>AT168709 NZ_CP076232:c473601-473323 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References