Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 880489..881131 Replicon chromosome
Accession NZ_CP059331
Organism Mannheimia haemolytica strain 0597

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H1C99_RS04340 Protein ID WP_020831140.1
Coordinates 880489..880740 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H1C99_RS04345 Protein ID WP_240030426.1
Coordinates 880856..881131 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C99_RS04320 875625..877736 + 2112 WP_240030295.1 restriction endonuclease subunit S -
H1C99_RS04325 (H1C99_04315) 877739..878377 + 639 WP_240030296.1 hypothetical protein -
H1C99_RS04330 (H1C99_04320) 878594..879343 - 750 WP_006251875.1 ABC transporter ATP-binding protein -
H1C99_RS04335 (H1C99_04325) 879340..880308 - 969 WP_240027582.1 iron ABC transporter permease -
H1C99_RS04340 (H1C99_04330) 880489..880740 + 252 WP_020831140.1 hypothetical protein Toxin
H1C99_RS04345 (H1C99_04335) 880856..881131 + 276 WP_240030426.1 putative addiction module antidote protein Antitoxin
H1C99_RS04350 881121..881876 - 756 WP_240030427.1 helical backbone metal receptor -
H1C99_RS04355 882693..883007 - 315 Protein_821 TonB-dependent receptor plug domain-containing protein -
H1C99_RS04360 (H1C99_04345) 883055..883837 + 783 WP_006249044.1 methylenetetrahydrofolate reductase -
H1C99_RS04365 (H1C99_04350) 883886..885046 - 1161 WP_142777976.1 hypothetical protein -
H1C99_RS04370 (H1C99_04355) 885106..886122 - 1017 WP_020831141.1 UDP-glucose 4-epimerase GalE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-81)

Antitoxin

Uncharacterized protein HI1420

(5-88)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9533.89 Da        Isoelectric Point: 8.3463

>T168705 WP_020831140.1 NZ_CP059331:880489-880740 [Mannheimia haemolytica]
MYHIERTEIFDQWLENLKDPLAVVTIARRIERAESGNFGDTKYIAEGISEMRLNVSKGYRLYYAQKGSIIYILLNGGYKG
TPS

Download         Length: 252 bp

>T168705 NZ_CP076231:56782-57057 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10025.46 Da        Isoelectric Point: 4.6283

>AT168705 WP_240030426.1 NZ_CP059331:880856-881131 [Mannheimia haemolytica]
MGITEFDAAEYLTNDELIALYLAETLKDGTDEEFIQALNTVARAKGMNELAKKAGIGRESLYQSLSSSKPRFETIRKIIS
ALNLELSVVKA

Download         Length: 276 bp

>AT168705 NZ_CP076231:56498-56782 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References