Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 796165..796818 Replicon chromosome
Accession NZ_CP059331
Organism Mannheimia haemolytica strain 0597

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1C99_RS03960 Protein ID WP_240028655.1
Coordinates 796429..796818 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1C99_RS03955 Protein ID WP_240027552.1
Coordinates 796165..796428 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C99_RS03940 (H1C99_03920) 791850..795386 + 3537 WP_240030277.1 transcription-repair coupling factor -
H1C99_RS03945 (H1C99_03925) 795550..795836 + 287 Protein_743 BrnT family toxin -
H1C99_RS03950 (H1C99_03930) 795837..796049 + 213 WP_006251765.1 BrnA antitoxin family protein -
H1C99_RS03955 (H1C99_03935) 796165..796428 + 264 WP_240027552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H1C99_RS03960 (H1C99_03940) 796429..796818 + 390 WP_240028655.1 type II toxin-antitoxin system VapC family toxin Toxin
H1C99_RS03965 (H1C99_03945) 796838..798076 + 1239 WP_006251767.1 peptidase T -
H1C99_RS03990 (H1C99_03970) 798736..799524 + 789 WP_240030278.1 GDP-L-fucose synthase -
H1C99_RS03995 (H1C99_03975) 799598..800458 + 861 WP_240020774.1 metal ABC transporter permease -
H1C99_RS04000 (H1C99_03980) 800451..801259 + 809 Protein_750 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14412.70 Da        Isoelectric Point: 7.7416

>T168704 WP_240028655.1 NZ_CP059331:796429-796818 [Mannheimia haemolytica]
MYMLDTNTVSFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLGYFLSSVKVLDWNYRCAELYGKLR
AEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T168704 NZ_CP076231:12806-13111 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10373.67 Da        Isoelectric Point: 4.8951

>AT168704 WP_240027552.1 NZ_CP059331:796165-796428 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKKERNQSFEQ
RDPFEVA

Download         Length: 264 bp

>AT168704 NZ_CP076231:12586-12804 [Escherichia coli O157:H7]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References