Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 248853..249445 Replicon chromosome
Accession NZ_CP059331
Organism Mannheimia haemolytica strain 0597

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1C99_RS01315 Protein ID WP_006250491.1
Coordinates 249017..249445 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1C99_RS01310 Protein ID WP_240018773.1
Coordinates 248853..249017 (+) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C99_RS01285 244330..244395 - 66 Protein_233 PT domain-containing protein -
H1C99_RS01295 (H1C99_01260) 244566..246281 - 1716 WP_240030152.1 proline--tRNA ligase -
H1C99_RS01300 (H1C99_01265) 246444..246593 - 150 WP_240027382.1 hypothetical protein -
H1C99_RS01305 (H1C99_01270) 246682..248568 - 1887 WP_240030153.1 molecular chaperone HtpG -
H1C99_RS01310 248853..249017 + 165 WP_240018773.1 hypothetical protein Antitoxin
H1C99_RS01315 (H1C99_01280) 249017..249445 + 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
H1C99_RS01320 (H1C99_01285) 249449..251530 + 2082 WP_006250490.1 ATP-dependent DNA helicase RecG -
H1C99_RS01325 (H1C99_01290) 251552..252430 - 879 WP_240030420.1 nucleoside hydrolase -
H1C99_RS01330 (H1C99_01295) 252536..254188 - 1653 WP_006250488.1 phospho-sugar mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T168703 WP_006250491.1 NZ_CP059331:249017-249445 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

>T168703 NZ_CP076230:c5084602-5084429 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6443.93 Da        Isoelectric Point: 3.8960

>AT168703 WP_240018773.1 NZ_CP059331:248853-249017 [Mannheimia haemolytica]
MDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVEIRKSNKPRPVDFGDE

Download         Length: 165 bp

>AT168703 NZ_CP076230:c5084926-5084630 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References