Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1845649..1846254 Replicon chromosome
Accession NZ_CP059330
Organism Mannheimia haemolytica strain 0722

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D00_RS09145 Protein ID WP_240018543.1
Coordinates 1845649..1846038 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1D00_RS09150 Protein ID WP_240021157.1
Coordinates 1846039..1846254 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D00_RS09100 (H1D00_09155) 1841077..1841885 - 809 Protein_1790 metal ABC transporter permease -
H1D00_RS09105 (H1D00_09160) 1841878..1842738 - 861 WP_240021155.1 metal ABC transporter permease -
H1D00_RS09110 (H1D00_09165) 1842812..1843603 - 792 WP_240021156.1 GDP-L-fucose synthase -
H1D00_RS09140 (H1D00_09195) 1844391..1845629 - 1239 WP_006251767.1 peptidase T -
H1D00_RS09145 (H1D00_09200) 1845649..1846038 - 390 WP_240018543.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D00_RS09150 (H1D00_09205) 1846039..1846254 - 216 WP_240021157.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H1D00_RS09155 (H1D00_09210) 1846414..1846626 - 213 WP_006251765.1 BrnA antitoxin family protein -
H1D00_RS09160 1846627..1846716 - 90 WP_240018853.1 BrnT family toxin -
H1D00_RS09165 1846782..1846913 - 132 Protein_1798 BrnT family toxin -
H1D00_RS09170 (H1D00_09220) 1847076..1850612 - 3537 WP_240021158.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14575.87 Da        Isoelectric Point: 7.7391

>T168698 WP_240018543.1 NZ_CP059330:c1846038-1845649 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLGYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T168698 NZ_CP076230:4243390-4243608 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8459.41 Da        Isoelectric Point: 4.2340

>AT168698 WP_240021157.1 NZ_CP059330:c1846254-1846039 [Mannheimia haemolytica]
VRLPVEFEFDAEQVYVSKQENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQRDPFEVA

Download         Length: 216 bp

>AT168698 NZ_CP076230:4242990-4243364 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References