Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 43204..43852 | Replicon | chromosome |
Accession | NZ_CP059330 | ||
Organism | Mannheimia haemolytica strain 0722 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A249A099 |
Locus tag | H1D00_RS00215 | Protein ID | WP_006251221.1 |
Coordinates | 43204..43380 (+) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A248ZZL6 |
Locus tag | H1D00_RS00220 | Protein ID | WP_006251222.1 |
Coordinates | 43436..43852 (+) | Length | 139 a.a. |
Genomic Context
Location: 42189..42422 (234 bp)
Type: Others
Protein ID: WP_020824316.1
Type: Others
Protein ID: WP_020824316.1
Location: 43204..43380 (177 bp)
Type: Toxin
Protein ID: WP_006251221.1
Type: Toxin
Protein ID: WP_006251221.1
Location: 43436..43852 (417 bp)
Type: Antitoxin
Protein ID: WP_006251222.1
Type: Antitoxin
Protein ID: WP_006251222.1
Location: 38516..41011 (2496 bp)
Type: Others
Protein ID: WP_240021404.1
Type: Others
Protein ID: WP_240021404.1
Location: 41098..41493 (396 bp)
Type: Others
Protein ID: WP_006251217.1
Type: Others
Protein ID: WP_006251217.1
Location: 41560..42018 (459 bp)
Type: Others
Protein ID: WP_006251218.1
Type: Others
Protein ID: WP_006251218.1
Location: 42437..43102 (666 bp)
Type: Others
Protein ID: WP_240021405.1
Type: Others
Protein ID: WP_240021405.1
Location: 43892..44374 (483 bp)
Type: Others
Protein ID: WP_006251223.1
Type: Others
Protein ID: WP_006251223.1
Location: 44378..44758 (381 bp)
Type: Others
Protein ID: WP_006251224.1
Type: Others
Protein ID: WP_006251224.1
Location: 44755..45123 (369 bp)
Type: Others
Protein ID: WP_006251225.1
Type: Others
Protein ID: WP_006251225.1
Location: 45125..45295 (171 bp)
Type: Others
Protein ID: WP_021280623.1
Type: Others
Protein ID: WP_021280623.1
Location: 45850..46101 (252 bp)
Type: Others
Protein ID: WP_015484272.1
Type: Others
Protein ID: WP_015484272.1
Location: 46113..47099 (987 bp)
Type: Others
Protein ID: WP_240021406.1
Type: Others
Protein ID: WP_240021406.1
Location: 47114..47548 (435 bp)
Type: Others
Protein ID: WP_006251230.1
Type: Others
Protein ID: WP_006251230.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H1D00_RS00190 (H1D00_00185) | 38516..41011 | - | 2496 | WP_240021404.1 | phage tail length tape measure family protein | - |
H1D00_RS00195 (H1D00_00190) | 41098..41493 | - | 396 | WP_006251217.1 | hypothetical protein | - |
H1D00_RS00200 (H1D00_00195) | 41560..42018 | - | 459 | WP_006251218.1 | hypothetical protein | - |
H1D00_RS00205 (H1D00_00200) | 42189..42422 | + | 234 | WP_020824316.1 | hypothetical protein | - |
H1D00_RS00210 (H1D00_00205) | 42437..43102 | - | 666 | WP_240021405.1 | DUF6246 family protein | - |
H1D00_RS00215 (H1D00_00210) | 43204..43380 | + | 177 | WP_006251221.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
H1D00_RS00220 (H1D00_00215) | 43436..43852 | + | 417 | WP_006251222.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
H1D00_RS00225 (H1D00_00220) | 43892..44374 | - | 483 | WP_006251223.1 | phage tail tube protein | - |
H1D00_RS00230 (H1D00_00225) | 44378..44758 | - | 381 | WP_006251224.1 | hypothetical protein | - |
H1D00_RS00235 (H1D00_00230) | 44755..45123 | - | 369 | WP_006251225.1 | hypothetical protein | - |
H1D00_RS00240 | 45125..45295 | - | 171 | WP_021280623.1 | hypothetical protein | - |
H1D00_RS00245 (H1D00_00245) | 45850..46101 | - | 252 | WP_015484272.1 | hypothetical protein | - |
H1D00_RS00250 (H1D00_00250) | 46113..47099 | - | 987 | WP_240021406.1 | encapsulin | - |
H1D00_RS00255 (H1D00_00255) | 47114..47548 | - | 435 | WP_006251230.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 29531..85647 | 56116 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6640.79 Da Isoelectric Point: 10.7708
>T168694 WP_006251221.1 NZ_CP059330:43204-43380 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK
Download Length: 177 bp
>T168694 NZ_CP076230:c3363649-3363275 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15519.91 Da Isoelectric Point: 4.3508
>AT168694 WP_006251222.1 NZ_CP059330:43436-43852 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG
Download Length: 417 bp
>AT168694 NZ_CP076230:c3364070-3363696 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A249A099 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A248ZZL6 |