Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 43204..43852 Replicon chromosome
Accession NZ_CP059330
Organism Mannheimia haemolytica strain 0722

Toxin (Protein)


Gene name hicA Uniprot ID A0A249A099
Locus tag H1D00_RS00215 Protein ID WP_006251221.1
Coordinates 43204..43380 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A248ZZL6
Locus tag H1D00_RS00220 Protein ID WP_006251222.1
Coordinates 43436..43852 (+) Length 139 a.a.

Genomic Context


H1D00_RS00205H1D00_RS00215H1D00_RS00220H1D00_RS00190H1D00_RS00195H1D00_RS00200H1D00_RS00210H1D00_RS00225H1D00_RS00230H1D00_RS00235H1D00_RS00240H1D00_RS00245H1D00_RS00250H1D00_RS00255
Location: 42189..42422 (234 bp)
Type: Others
Protein ID: WP_020824316.1
Location: 43204..43380 (177 bp)
Type: Toxin
Protein ID: WP_006251221.1
Location: 43436..43852 (417 bp)
Type: Antitoxin
Protein ID: WP_006251222.1
Location: 38516..41011 (2496 bp)
Type: Others
Protein ID: WP_240021404.1
Location: 41098..41493 (396 bp)
Type: Others
Protein ID: WP_006251217.1
Location: 41560..42018 (459 bp)
Type: Others
Protein ID: WP_006251218.1
Location: 42437..43102 (666 bp)
Type: Others
Protein ID: WP_240021405.1
Location: 43892..44374 (483 bp)
Type: Others
Protein ID: WP_006251223.1
Location: 44378..44758 (381 bp)
Type: Others
Protein ID: WP_006251224.1
Location: 44755..45123 (369 bp)
Type: Others
Protein ID: WP_006251225.1
Location: 45125..45295 (171 bp)
Type: Others
Protein ID: WP_021280623.1
Location: 45850..46101 (252 bp)
Type: Others
Protein ID: WP_015484272.1
Location: 46113..47099 (987 bp)
Type: Others
Protein ID: WP_240021406.1
Location: 47114..47548 (435 bp)
Type: Others
Protein ID: WP_006251230.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H1D00_RS00190 (H1D00_00185)38516..41011-2496WP_240021404.1phage tail length tape measure family protein-
H1D00_RS00195 (H1D00_00190)41098..41493-396WP_006251217.1hypothetical protein-
H1D00_RS00200 (H1D00_00195)41560..42018-459WP_006251218.1hypothetical protein-
H1D00_RS00205 (H1D00_00200)42189..42422+234WP_020824316.1hypothetical protein-
H1D00_RS00210 (H1D00_00205)42437..43102-666WP_240021405.1DUF6246 family protein-
H1D00_RS00215 (H1D00_00210)43204..43380+177WP_006251221.1type II toxin-antitoxin system HicA family toxinToxin
H1D00_RS00220 (H1D00_00215)43436..43852+417WP_006251222.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
H1D00_RS00225 (H1D00_00220)43892..44374-483WP_006251223.1phage tail tube protein-
H1D00_RS00230 (H1D00_00225)44378..44758-381WP_006251224.1hypothetical protein-
H1D00_RS00235 (H1D00_00230)44755..45123-369WP_006251225.1hypothetical protein-
H1D00_RS0024045125..45295-171WP_021280623.1hypothetical protein-
H1D00_RS00245 (H1D00_00245)45850..46101-252WP_015484272.1hypothetical protein-
H1D00_RS00250 (H1D00_00250)46113..47099-987WP_240021406.1encapsulin-
H1D00_RS00255 (H1D00_00255)47114..47548-435WP_006251230.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--29531..8564756116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6640.79 Da        Isoelectric Point: 10.7708

>T168694 WP_006251221.1 NZ_CP059330:43204-43380 [Mannheimia haemolytica]
VKQSEFLRWLKANGVEVENGSKHLKLYYKGKRSHLPKHPSQELKTGLVEGVKKQLGLK

Download         Length: 177 bp

>T168694 NZ_CP076230:c3363649-3363275 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15519.91 Da        Isoelectric Point: 4.3508

>AT168694 WP_006251222.1 NZ_CP059330:43436-43852 [Mannheimia haemolytica]
MFYPALFTPAEEGGFVVTFPDLPEAITQGDTFEEAMEMAEDVLLSCVEIYFDEDRRFPLTRPVNTDEVPVFMPESIYAKV
LLHNTMQEQAVSKAEIARLTNIRPPEVQRILAPRHITKIDTIGRILASLGKPLQLSLG

Download         Length: 417 bp

>AT168694 NZ_CP076230:c3364070-3363696 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A249A099


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A248ZZL6

References