Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1404398..1404990 Replicon chromosome
Accession NZ_CP059329
Organism Mannheimia haemolytica strain 0727

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D01_RS07105 Protein ID WP_006250491.1
Coordinates 1404398..1404826 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1D01_RS07110 Protein ID WP_240018773.1
Coordinates 1404826..1404990 (-) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D01_RS07090 (H1D01_07150) 1399652..1401304 + 1653 WP_240024852.1 phospho-sugar mutase -
H1D01_RS07095 (H1D01_07155) 1401314..1402291 + 978 WP_275672160.1 nucleoside hydrolase -
H1D01_RS07100 (H1D01_07160) 1402313..1404394 - 2082 WP_006248274.1 ATP-dependent DNA helicase RecG -
H1D01_RS07105 (H1D01_07165) 1404398..1404826 - 429 WP_006250491.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D01_RS07110 1404826..1404990 - 165 WP_240018773.1 hypothetical protein Antitoxin
H1D01_RS07115 (H1D01_07175) 1405274..1407157 + 1884 WP_006248270.1 molecular chaperone HtpG -
H1D01_RS07120 1407210..1407371 + 162 WP_015483997.1 hypothetical protein -
H1D01_RS07125 (H1D01_07180) 1407534..1409249 + 1716 WP_240024853.1 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16640.06 Da        Isoelectric Point: 8.9269

>T168690 WP_006250491.1 NZ_CP059329:c1404826-1404398 [Mannheimia haemolytica]
MYRYLFDTNIVSELYKLRNDKMDVNVRQWLRGVNPSQTNISCITLSEIKTGILLKARKDKEQSDRLNDWFENNVLKAYQT
KAFVVNNDIALLASEYHIPNKMDLNDAYIAATAKYHNLILVTRNTKDFIRCDVRLFNPFETA

Download         Length: 429 bp

>T168690 NZ_CP076230:c2622251-2621973 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 6443.93 Da        Isoelectric Point: 3.8960

>AT168690 WP_240018773.1 NZ_CP059329:c1404990-1404826 [Mannheimia haemolytica]
MDYQQKKPSEPSFEELFASSENEDVSDEFWQEFEQTLVEIRKSNKPRPVDFGDE

Download         Length: 165 bp

>AT168690 NZ_CP076230:c2622444-2622253 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References