Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 859796..860449 Replicon chromosome
Accession NZ_CP059329
Organism Mannheimia haemolytica strain 0727

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1D01_RS04455 Protein ID WP_240026071.1
Coordinates 859796..860185 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1D01_RS04460 Protein ID WP_240026072.1
Coordinates 860186..860449 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D01_RS04410 (H1D01_04455) 855263..856071 - 809 Protein_883 metal ABC transporter permease -
H1D01_RS04415 (H1D01_04460) 856064..856930 - 867 WP_240026068.1 metal ABC transporter permease -
H1D01_RS04420 (H1D01_04465) 857004..857792 - 789 WP_240026069.1 GDP-L-fucose synthase -
H1D01_RS04450 (H1D01_04495) 858535..859776 - 1242 WP_240026070.1 peptidase T -
H1D01_RS04455 (H1D01_04500) 859796..860185 - 390 WP_240026071.1 type II toxin-antitoxin system VapC family toxin Toxin
H1D01_RS04460 (H1D01_04505) 860186..860449 - 264 WP_240026072.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H1D01_RS04465 (H1D01_04510) 860565..860777 - 213 WP_006251765.1 BrnA antitoxin family protein -
H1D01_RS04470 (H1D01_04515) 860778..861065 - 288 WP_240026073.1 BrnT family toxin -
H1D01_RS04475 (H1D01_04520) 861227..864763 - 3537 WP_240026074.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T168689 WP_240026071.1 NZ_CP059329:c860185-859796 [Mannheimia haemolytica]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T168689 NZ_CP076230:2347641-2347744 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10358.70 Da        Isoelectric Point: 4.8951

>AT168689 WP_240026072.1 NZ_CP059329:c860449-860186 [Mannheimia haemolytica]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSIKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQ
RDPFEVA

Download         Length: 264 bp

>AT168689 NZ_CP076230:c2347782-2347511 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References